Evidence map›Paper›PMID 39845826›Full record

ArticleFrontiers in medicine2024

Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort.

Sarah Damanti, Rebecca De Lorenzo, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Maria Pia Ruggiero, Simona Santoro, Eleonora Senini and 8 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Monocytes are biological sensors of aging and frailty in humans.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah DamantiInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Rebecca De LorenzoInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Lorena CitterioNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Laura ZagatoNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Elena BrioniInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cristiano MagnaghiScientific Technical Secretariat of the Ethics Committee. IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marco SimoniniNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maria Pia RuggieroVita-Salute San Raffaele University, Milan, Italy.
Simona SantoroVita-Salute San Raffaele University, Milan, Italy.
Eleonora SeniniVita-Salute San Raffaele University, Milan, Italy.
Marco MessinaVita-Salute San Raffaele University, Milan, Italy.
Francesca FarinaVita-Salute San Raffaele University, Milan, Italy.
Costanza FestorazziVita-Salute San Raffaele University, Milan, Italy.
Giordano VitaliInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paolo ManuntaVita-Salute San Raffaele University, Milan, Italy.
Angelo Andrea ManfrediVita-Salute San Raffaele University, Milan, Italy.
Chiara LanzaniVita-Salute San Raffaele University, Milan, Italy.
Patrizia Rovere-QueriniInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Frailty, a geriatric syndrome associated with adverse outcomes, lacks a universal definition. No consensus exists on the most effective frailty scale for predicting mortality. Methods: This prospective observational study followed community-dwelling volunteers for 6 years. Frailty was measured with the Frailty Index (FI) and the Frailty Phenotype (FP). Concordance was assessed using Cohen's Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality. Results: Out of 1,114 participants (median age 72 years, IQR 69-77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. The concordance between the two measures was fair ( Conclusion: Definitions of frailty identify different individuals as frail. The FI was more closely related to mortality than the FP. Individuals classified as frail according to both definitions displayed the highest complexity (corresponding also ho higher FI scores) and the greatest mortality. The FI demonstrated a more accurate ability to predict mortality due to its comprehensive nature.

Indexed as

community dwelling older peoplefrailty indexfrailty phenotypemortalityolder people

Identifiers

PMID39845826
PMCPMC11750773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.