Evidence map›Paper›PMID 39845654›Full record

ArticleFrontiers in public health2024

Assessment of access and outcomes of kidney transplantation through the reforms of the Swiss organ allocation system.

Massimiliano Bertacchi, Sylvie Ferrari-Lacraz, Jakob Nilsson, Agim Thaqi, Yvan Schmutz, Caroline Wehmeier, Thomas Schachtner, Thomas Mueller, Dela Golshayan, Julien Vionnet and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Massimiliano BertacchiNephrology and Hypertension Division, Geneva University Hospitals, Geneva, Switzerland.
Sylvie Ferrari-LacrazTransplant Immunology Unit, Geneva University Hospitals, Geneva, Switzerland.
Jakob NilssonDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Agim ThaqiFederal Office of Public Health, Bern, Switzerland.
Yvan SchmutzAnalytica SA, Lausanne, Switzerland.
Caroline WehmeierNephrology and Transplant Immunology Division, University Hospital Basel, Basel, Switzerland.
Thomas SchachtnerNephrology Division, University Hospital Zurich, Zurich, Switzerland.
Thomas MuellerNephrology Division, University Hospital Zurich, Zurich, Switzerland.
Dela GolshayanTransplantation Center, Centre Hospitaliser Universitaire Vaudois, Lausanne, Switzerland.
Julien VionnetDivision of Immunology and Allergy, Centre Hospitaliser Universitaire Vaudois, Lausanne, Switzerland.
Stefan SchaubNephrology and Transplant Immunology Division, University Hospital Basel, Basel, Switzerland.
Fadi HaidarNephrology and Hypertension Division, Geneva University Hospitals, Geneva, Switzerland.
Isabelle BinetClinic for Nephrology and Transplantation Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Jutta ThierbachBlood Transfusion Service Eastern Switzerland, Swiss Red Cross, St. Gallen, Switzerland.
Urs WirthmuellerDepartment of Laboratory Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.
Daniel SidlerDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, Bern, Switzerland.
Franz ImmerSwisstransplant, The Swiss National Foundation for Organ Donation and Transplantation, Bern, Switzerland.
Jean VillardTransplant Immunology Unit, Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The Swiss allocation system for kidney transplantation has evolved over time to balance medical urgency, immunological compatibility, and waiting time. Since the introduction of the transplantation law in 2007, which imposed organ allocation on a national level, the algorithm has been optimized. Initially based on waiting time, HLA compatibility, and crossmatch performed by cell complement-dependent cytotoxicity techniques, the system moved in 2012 to a score including HLA compatibility, waiting time, anti-HLA antibodies detected by the Luminex Methods: We reviewed access to transplants and post-transplant outcomes along those changes, defining three periods (v0: 2007-2012, v1: 2012-2015, v2: 2015-2020). Results: Changes in the Swiss allocation system improved the fairness of access to transplantation, particularly for hyperimmunized patients. However, the system still fails to grant fair access to some blood groups. Furthermore, our data showed that rule modifications did not impact early post-transplant complications, maintaining similar time to first rejection and 1-year graft survival across subgroups. Discussion: Such an analysis is useful for validating changes made to the allocation system and identifying aspects that need to be implemented in future revisions.

Indexed as

Health Services AccessibilityKidney TransplantationTissue and Organ ProcurementAdultFemaleGraft SurvivalHumansMaleMiddle AgedSwitzerlandWaiting Listsallocation fairnessallocation systemhyperimmunized patientskidney transplantationtransplant immunologywaiting time

Identifiers

PMID39845654
PMCPMC11751015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.