ArticleSurgery in practice and science2022
Reducing opioid consumption levels post-operatively following gastrointestinal surgery - A systematic review of randomized trials.
Article in Surgery in practice and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The opioid crisis has reached epidemic proportions worldwide. Unfortunately, prescription of opioid analgesia in the post-operative phase of treatment is contributing to this problem. We aimed to perform a systematic review of randomized controlled trials to establish methods of reducing opioid toxicity following gastrointestinal surgery. Materials and methods: A systematic review was performed in accordance to the PRISMA guidelines. Randomized controlled trials were included. The risk of bias 2.0 assessment was used to determine potential bias. Results: In total, 14 prospective, randomized trials involving 1,687 patients (mean age: 50 years (range: 21-80) were included in this systematic review. Overall, 42.9% of trials reported outcomes in relation to intravenous infusion of analgesia and their impact on opioid consumption at discharge (6/14), 5 trials of which reported reduced consumptions levels (5/6, 83.3%). Overall, 28.6% of studies assessed the role of oral medications reducing the requirement for opioids post-operatively (4/14), of which, just one trial reported a significant effect of oral vitamin C supplementation compared to placebo. Overall, just one trial outlined the impact of the use of patient-controlled analgesia, ultrasound-guided nerve blocks, intramuscular anti-inflammatory gels, and the role of opioid-specific counselling in reducing opioid consumption post-operatively. Conclusion: This systematic review adds further data to the surgical literature regarding efficacious methods to tackle the 'opioid crisis'. Among the most promising avenues are opioid-specific counselling and peri‑operative prescription of intravenous infusions to counteract the increasing opioid consumption, which directly contributes to the 'opioid epidemic' for citizens across the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.