Evidence map›Paper›PMID 39845576›Full record

ArticleTherapeutic advances in neurological disorders2025

Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis.

Cédric Hirzel, Annina Grütter, Denis Grandgirard, Robert Hoepner, Franziska Suter-Riniker, Stephen L Leib

Abstract read
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In one paragraph

Article in Therapeutic advances in neurological disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cédric HirzelDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Hochshulstrasse 4, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0002-7870-912X
Annina GrütterDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Denis GrandgirardInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-4151-5196
Robert HoepnerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-0115-7021
Franziska Suter-RinikerInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Stephen L LeibInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-1106-6123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury. Objectives: To assess sNfL's utility as a diagnostic marker for Lyme neuroborreliosis (LNB). Methods: We compared serum and CSF NfL levels in LNB patients and age-matched controls. Age-adjusted NfL values were used in receiver operating characteristic (ROC) analysis. Design: Retrospective cohort study. Results: Eighty-six patients (30 LNB, 29 with-, and 27 without neurological disorders) were included. Compared to individuals without neurological disease, LNB patients showed increased serum (median (interquartile range, IQR): 36.3 pg/ml (19.3-112.0) vs 20 pg/ml (12.9-37.3), Conclusion: sNfL concentrations lack sufficient diagnostic capability for LNB diagnosis.

Indexed as

cerebrospinal fluiddiagnostic test studyLyme neuroborreliosisneurofilament light chainserum

Identifiers

PMID39845576
PMCPMC11752212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.