ArticleSexual medicine2024
Nutraceutical and low energy shockwave treatments improved sexual function recovery in a rat pelvic neurovascular injury model.
Article in Sexual medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Phytochemical-based nanomedicine as a promising therapeutic strategy for erectile dysfunction.Asian journal of andrology · 2026Review
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Authors and funding
5 authors.
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Abstract
Background: Pelvic trauma can have long-lasting debilitating effects, including severe erectile dysfunction (ED) in men. While there are effective treatments for ED, these treat the symptoms not the cause. Those who suffer from an acute traumatic injury to the neurovascular supply of penis, may benefit from regenerative therapy. COMP4 is an all-natural herbal compound (Muira puama, Aim: To investigate the effects of the COMP4 and LESW for the treatment of ED in a rat pelvic trauma model. Methods: The experimental design included five groups (Lewis rats aged 10-12 weeks; n = 8/group): (1) Sham, (2) Injury control, (3) Peanut Butter (PNB; Vehicle) Control, (4) COMP4, and (5) COMP4 + LESW. Pelvic neurovascular injury (PNVI) was induced by performing bilateral cavernous nerve crush injury and internal pudendal bundle ligation under general anesthesia. One week after PNVI rats received COMP4 (45 mg/kg b.wt./day) orally via PNB and/or LESW (1000 pulses at 0.06 mJ/mm2, 3 Hz, three times per week to the pelvis around penis) for 6 weeks. After 1 week of washout period, erectile function (EF) was assessed via intracavernous pressure (ICP; mmHg) measurements; rats euthanized, penile tissues collected for analyses. Outcomes: COMP4 and LESW treatments improved EF recovery. Results: There was a significant ( Clinical Implications: COMP4 and/or LESW can serve as an adjunct therapy to mitigate ED. Strengths and Limitations: Identified novel treatment option to improve EF recovery. Unable to address in-depth cellular/molecular mechanisms. Conclusions: COMP4 and LESW treatments appear to be promising to improve clinical EF recovery in pelvic trauma.
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