Evidence map›Paper›PMID 39845302›Full record

ArticleSurgery in practice and science2023

High flow cooled air can decrease brain temperature without injuring the snout or brain in Swine.

David P Stonko, Michael J Richmond, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Noha Elansary, Neerav Patel, Neeraj Badjatia, Kyle Jewhurst, Michaelina Dupnik and 3 more

Abstract read
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In one paragraph

Article in Surgery in practice and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David P StonkoDepartment of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Michael J RichmondR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Joseph EdwardsR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Hossam AbdouR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Rebecca TreffallsR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Noha ElansaryR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Neerav PatelR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Neeraj BadjatiaR Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA.
Kyle JewhurstVivonics Inc, Massachusetts, USA.
Michaelina DupnikVivonics Inc, Massachusetts, USA.
Kristian DiMatteoVivonics Inc, Massachusetts, USA.
Ryan MyersVivonics Inc, Massachusetts, USA.
Jonathan J MorrisonDivision of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Targeted temperature management plays an important role in the treatment of myriad critical illnesses. Non-invasive, quick-onset options for isolated brain temperature control remain lacking. The goal of this study was to assess the safety and efficacy of a novel intranasal high flow cooled air device using a large animal model. Methods: Yorkshire swine were instrumented with temperature probes in the rectum, brain, ear, and snout, and a novel intranasal cooled air device was applied to half. The primary outcome was effectiveness of brain and snout cooling by the study device. Secondary outcomes included tympanic cooling and absence of rectal cooling, CT, CT perfusion, and histologic evidence of injury in the short- and medium-term. Results: 10 animals (54.7 kgs.+/- 19.4 SD) underwent non-survival evaluation, 3 underwent delayed evaluation (56.1 kgs.+/-6.4). From baseline to cooling period, intranasal (38.1 °C vs. 34.9 °C, Conclusion: This novel, non-invasive, intranasal high flow cooled air device provides isolated brain and head cooling without any evidence injury in the short or medium term.

Indexed as

Brain traumaCNS injuryIsolated brain coolingNeurocritical careTemperature management

Identifiers

PMID39845302
PMCPMC11750019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.