ArticleCureus2024
Correlation Between Ki-67 Expression and Tumor Grade in Breast Cancer: A Cross-Sectional Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The GAPP Aggressivity Score Correlates with Total Enriched Somatic Variant Burden in Sporadic Pheochromocytoma-A Pilot Study.Cancers · 2026Article
- Arctigenin Suppresses Breast Cancer Growth In Vitro and In Vivo Through Subtype-Specific Multi-Targeting Activity.International journal of molecular sciences · 2026Article
- Endometrial Hyperplasia: Current Insights into Epidemiology, Risk Factors, and Clinical Management.Cancers · 2025Review
- A Simplified Novel Algorithm to Predict the 21-Gene Recurrence Score.World journal of oncology · 2025Article
- Ki67 Expression and Its Association With Clinicopathological Factors and Intrinsic Subtypes of Male Breast Cancer in Uganda: A Cross-sectional Study.Breast cancer : basic and clinical research · 2025Article
- Utility of Ki-67 index combined with alpha-fetoprotein and lactate dehydrogenase in distinguishing mature from immature ovarian teratomas in children.Frontiers in neurologyArticle
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Authors and funding
8 authors.
Funding
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Abstract
Introduction Ki-67 is a proliferation marker that may correlate with tumor grade in breast cancer. This study explores the association between Ki-67 expression levels and tumor grade in breast cancer patients. Materials and methods This cross-sectional study analyzed Ki-67 expression in tumor samples from 280 breast cancer patients. Ki-67 expression ranged from 5% to 50%, and was categorized alongside tumor grades (Grade 1, Grade 2, Grade 3). Statistical analysis included Spearman correlation and multivariate analysis. Results A significant positive correlation was observed between Ki-67 levels and tumor grades. Mean Ki-67 expression was 15.8% for Grade 1 tumors, 23.2% for Grade 2, and 34.7% for Grade 3 (Spearman correlation coefficient = 0.68, p < 0.001). Multivariate analysis indicated that high Ki-67 expression (≥25%) was independently associated with Grade 3 tumors, especially in triple-negative breast cancers. Conclusions Ki-67 expression strongly correlates with tumor grade and can serve as a prognostic indicator in breast cancer management, particularly in identifying aggressive tumor subtypes.
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