Evidence map›Paper›PMID 39845176›Full record

ReviewMycobiology2024

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment.

Khushbu Wadhwa, Neha Kapoor, Hardeep Kaur, Eman A Abu-Seer, Mohd Tariq, Sazada Siddiqui, Virendra Kumar Yadav, Parwiz Niazi, Pankaj Kumar, Saad Alghamdi

Abstract readReview
In one paragraph

Review in Mycobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
  2. Article
  3. Functional Characterization of Two Adjacent Oxygenase Genes,Journal of fungi (Basel, Switzerland) · 2026
    Article
  4. Ibotenic Acid and Muscimol inMolecules (Basel, Switzerland) · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Opportunistic pathogenicity in fungi can transcend species boundaries.bioRxiv : the preprint server for biology · 2026
    Article
  9. Phytochemical Profiling ofPlants (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Genetic Dereplication of MultipleJournal of natural products · 2026
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Khushbu WadhwaDepartment of Zoology, Ramjas College, University of Delhi, Delhi, India.
Neha KapoorDepartment of Chemistry, Hindu College, University of Delhi, Delhi, India.
Hardeep KaurDepartment of Zoology, Ramjas College, University of Delhi, Delhi, India.
Eman A Abu-SeerDepartment of Epidemiology and Medical Statistics, Faculty of Public Health and Health Informatics, Umm Al-Qura University, Mecca, Saudi Arabia.
Mohd TariqDepartment of Life Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat, India.
Sazada SiddiquiDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Virendra Kumar YadavMarwadi University Research Center, Department of Microbiology, Faculty of Sciences, Marwadi University, Rajkot, Gujarat, India.
Parwiz NiaziDepartment of Biology, Faculty of Education, Kandahar University, Kandahar, Afghanistan.
Pankaj KumarDepartment of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat, India.
Saad AlghamdiDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0003-4532-9128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of their growth, which are categorized into terpenoids, alkaloids, polyketides, and non-ribosomal peptides. These SMs exhibit significant biological activity, which contributes to the formulation of novel pharmaceuticals, biopesticides, and environmental bioremediation agents. Nowadays, these fungal-derived SMs are widely used in food and beverages, for fermentation, preservatives, protein sources, and in dairy industries. In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. The present review comprehensively analyses the diversity of fungal SMs along with their emerging applications in healthcare, agriculture, environmental sustainability, and nutraceuticals. Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. Finally, the authors have addressed the potential for genetic manipulation and biotechnological innovations for further exploitation of fungal SMs for commercial and environmental benefits.

Indexed as

gene clustershuman healthmycofiltrationmycoproteinSecondary metabolites

Identifiers

PMID39845176
PMCPMC11749308

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.