Evidence map›Paper›PMID 39845127›Full record

ArticleBiological psychiatry global open science2025

Increased Rate of Unique Mitochondrial DNA Deletion Breakpoints in Young Adults With Early-Life Stress.

Teresa E Daniels, Brooke E Hjelm, William W Lewis-de Los Angeles, Eric Smith, Audrey A Omidsalar, Brandi L Rollins, Anna Sherman, Stephanie Parade, Marquis P Vawter, Audrey R Tyrka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teresa E DanielsInitiative on Stress, Trauma, and Resilience, Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Brooke E HjelmDepartment of Translational Genomics, Keck School of Medicine of the University of Southern California, Los Angeles, California.
William W Lewis-de Los AngelesWarren Alpert Medical School, Brown University, Providence, Rhode Island.
Eric SmithWarren Alpert Medical School, Brown University, Providence, Rhode Island.
Audrey A OmidsalarDepartment of Translational Genomics, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Brandi L RollinsFunctional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, California.
Anna ShermanMood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, Rhode Island.
Stephanie ParadeInitiative on Stress, Trauma, and Resilience, Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Marquis P VawterFunctional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, California.
Audrey R TyrkaInitiative on Stress, Trauma, and Resilience, Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

Funding

Project 3: Isolating food insecurity to understand childhood health outcomes and biological mechanisms of riskP20GM139767 · NIGMS · MIRIAM HOSPITAL · PI KayLoni L. Olson · 2021 to 2026
$14.6M
Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
Promoting Research Training During Psychiatry ResidencyR25MH101076 · NIMH · BROWN UNIVERSITY · PI AUDREY TYRKA · 2013 to 2026
$2.8M
Early Life Stress: Epigenetic Regulation of Endocrine and Immune PathwaysR01MH101107 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2014 to 2018
$2.6M
Research Training in Childhood Stress, Trauma, and ResilienceT32HD101392 · NICHD · MIRIAM HOSPITAL · PI PARADE, STEPHANIE HART, STROUD, LAURA R · 2020 to 2024
$1.7M
Mechanisms of Accelerated Aging: Stress, Health Behaviors, and the Role of MitochondriaR21AG077332 · NIA · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2023 to 2024
$413k
NIA NIH HHS R21 AG077332NICHD NIH HHS T32 HD101392NIGMS NIH HHS P20 GM139767NIMH NIH HHS R01 MH085801NIMH NIH HHS R01 MH101107NIMH NIH HHS R25 MH101076
6 · The paper itself

Abstract

Background: Mounting evidence suggests that mitochondria respond to psychosocial stress. Recent studies suggest mitochondrial DNA (mtDNA) deletions may be increased in some psychiatric disorders, but no studies have examined early-life stress (ELS) and mtDNA deletions. In this study, we assessed mtDNA deletions in peripheral blood mononuclear cells of medically healthy young adults with and without ELS. Methods: Participants ( Results: Participants with ELS had significantly greater rates of unique mtDNA deletion breakpoints per 10,000 coverage than participants without ELS ( Conclusions: The increased number of unique mtDNA deletion breakpoints in participants with ELS suggests that mitochondrial genomes undergo observable alterations in the context of early stress. Future studies will examine mtDNA deletions with metabolic health measures.

Indexed as

Allostatic loadChildhood adversityEarly-life stressMitochondriamtDNAmtDNA deletions

Identifiers

PMID39845127
PMCPMC11751525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.