Evidence map›Paper›PMID 39844838›Full record

ArticleFrontiers in cellular and infection microbiology2024

Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Iara Barreto Neves Oliveira, Ramon Vieira Nunes, Vanessa Rafaela Milhomem Cruz Leite, Camila Freire Araújo, Murilo Barros Silveira, Sebastião Alves Pinto, Lorena Andrade Lamounier, Clayton Luiz Borges, Edésio Martins, Iane de Oliveira Pires Porto and 2 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iara Barreto Neves OliveiraLaboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Ramon Vieira NunesLaboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Vanessa Rafaela Milhomem Cruz LeiteLaboratório de Biologia Molecular (LBM), Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Camila Freire AraújoDepartment of Infectious Diseases, Hospital de Doenças Tropicais Dr. Anuar Auad, Goiânia, Goiás, Brazil.
Murilo Barros SilveiraLaboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Sebastião Alves PintoDepartment of Anatomopathology, Instituto Goiano de Oncologia e Hematologia (INGOH), Goiânia, Goiás, Brazil.
Lorena Andrade LamounierDepartment of Dermatology, Clínica São Braz, Goiânia, Brazil.
Clayton Luiz BorgesLaboratório de Biologia Molecular (LBM), Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Edésio MartinsDepartment of Morphofunctional Axis, Universidade de Rio Verde, Goiânia, Goiás, Brazil.
Iane de Oliveira Pires PortoDepartment of Morphofunctional Axis, Universidade de Rio Verde, Goiânia, Goiás, Brazil.
Rodrigo Saar Gomes *Laboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Fátima Ribeiro-Dias *Laboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The vitamin D pathway contributes to the microbicidal activity of macrophages against Methods: The expressions of Results: Vitamin D pathway-associated genes were expressed in cutaneous as well as mucosal lesions. Conclusions: Our findings suggested that some SNPs in the vitamin D pathway-associated genes can be related to resistance and therapeutic outcomes of ATL. They are promising candidates that need to be further evaluated to understand their biological effects in the control or immunopathogenesis of ATL.

Indexed as

Leishmaniasis, CutaneousPolymorphism, Single NucleotideVitamin D25-Hydroxyvitamin D3 1-alpha-HydroxylaseAdultCytokinesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedReceptors, CalcitriolTreatment OutcomeYoung Adult25-Hydroxyvitamin D3 1-alpha-HydroxylaseCYP27B1 protein, humanCytokinesReceptors, CalcitriolVDR protein, humanVitamin DCYP27B1interleukin-15interleukin-32Leishmania (Viannia)single nucleotide polymorphismvitamin D receptor

Identifiers

PMID39844838
PMCPMC11750871

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