Evidence map›Paper›PMID 39844722›Full record

ArticlePediatric blood & cancer2025

Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.

Sheila Terwisscha van Scheltinga, Reineke A Schoot, Jonathan C Routh, Guido Seitz, Simon C Kao, Bart de Keizer, Barry Shulkin, Roelof van Ewijk, Beth McCarville, Dana Casey and 17 more

Abstract readConsensus Statement
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Sheila Terwisscha van ScheltingaPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-7993-0208
Reineke A SchootPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jonathan C RouthDepartment of Urology, Duke University School of Medicine, Durham, North Carolina, USA.
Guido SeitzDepartment of Pediatric Surgery and Urology, University Hospital Giessen-Marburg, Marburg, Germany.
Simon C KaoDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Bart de KeizerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-6270-9483
Barry ShulkinDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0003-4784-7914
Roelof van EwijkPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Beth McCarvilleDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-2888-443X
Dana CaseyDepartment of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-6851-7653
Wendy Allen-RhoadesDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Federico MercoliniPediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Hans MerksPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Daniel OrbachSIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), PSL University, Institut Curie, Paris, France.ORCID https://orcid.org/0000-0002-2520-139X
Tejas KapadiaDepartment of Radiology, Royal Manchester Children's Hospital, Manchester, UK.
David O WalterhouseDivision of Hematology/Oncology/Stem Cell Transplant, Ann & Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, USA.
Raquel Davila FajardoPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-4729-825X
Laura Hiemcke-JiwaPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Christiane FranziusZentrum für Nuklearmedizin und PET/CT, Bremen, Germany.
Federica De CortiPediatric Surgery Unit, Woman's and Child's Health Department, University Hospital of Padova, Padova, Italy.
Vivian TangDepartment of Radiology, Royal Manchester Children's Hospital, Manchester, UK.
Jonathan MettsSarcoma Department, Moffitt Cancer Center, Tampa, Florida, USA.
Saphna OberoiDepartment of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0002-6071-0042
Christian VokuhlSection of Pediatric Pathology, Department of Pathology, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-4138-4536
Roshni DasguptaDivision of Pediatric General and Thoracic Surgery, Cincinnati Children׳s Hospital Medical Center, Cincinnati, Ohio, USA.
Suzi BirzDepartment of Pediatrics, University of Chicago, Chicago, Illinois, USA.
David RodebergDivision of Pediatric Surgery, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-3594-7547

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

Indexed as

Lymph NodesRhabdomyosarcomaSarcomaAdolescentChildChild, PreschoolEuropeHumansLymphatic MetastasisNeoplasm Stagingincluding soft tissuenon‐rhabdoidpediatric oncologyrhabdomyosarcomasarcomas

Identifiers

PMID39844722
PMCPMC12083081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.