ArticleJournal of rehabilitation medicine2025
Residual limb neuropathic pain association with neuroma, prosthetic, function, and participation outcomes in individuals living with a transtibial amputation: an exploratory study.
Article in Journal of rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The association between quality of life, anxiety and depression, and residual limb and phantom limb pain in war-related amputees: a year-long observational study.EClinicalMedicine · 2026Article
- Assessment of pain and functional outcomes after lower limb amputation: a scoping review.BMJ open · 2026Article
- Association Between the Microbiological Characteristics of Postoperative Stump Wound Infections and Neuropathic Pain After Limb Amputation: A Cross-Sectional Observational Study.Journal of pain research · 2026Article
- Preserved fascicular architecture predicts neuroma pain: a morphometric study.Acta neuropathologica communications · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the strength of the association between residual limb neuropathic pain intensity and the number of neuromas, prosthetic, functional, and participation outcomes, and assess whether ultrasound (US) biomarkers of neuromas differ between pain intensities.
designCross-sectional study. SUBJECTS: Twenty-two participants with a transtibial amputation for more than 12 months, with and without residual limb neuropathic pain.
methodsParticipants completed questionnaires (Numerical Pain Rating Scale, Pain Disability Index (PDI), Prosthetic Profile of the Amputee-Locomotor Capabilities Index), and had their residual limbs examined by US. Whenever a neuroma was diagnosed during US, images of the neuroma(s) were recorded and US biomarkers were computed.
resultsOf the 27 neuromas diagnosed, pain intensity was associated with no use of walking aid, less daily prosthesis wearing time, a higher PDI score, and a neuroma at the common fibular nerve. The cross-sectional area, the thickness ratio, or the thickness of the overlying tissues was not associated with pain intensity.
conclusionThough the results enrich currently available evidence on clinical variables potentially associated with the intensity of neuropathic pain in individuals living with a transtibial amputation, and on the limited value of US biomarkers studied to determine the association between neuroma(s) and pain intensity, future studies providing higher quality evidence remain needed.
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