Evidence map›Paper›PMID 39844577›Full record

ReviewBiochemistry2025

Glutamine Synthetase: Diverse Regulation and Functions of an Ancient Enzyme.

Markus C B Tecson, Cyrina Geluz, Yuly Cruz, Eric R Greene

Abstract readReview
In one paragraph

Review in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Glutamine metabolic enzymes: to filament or not to filament?Biochemical Society transactions · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Construction of RecombinantMicroorganisms · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Markus C B TecsonDepartment of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, United States.ORCID 0009-0004-6594-5467
Cyrina GeluzDepartment of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, United States.
Yuly CruzDepartment of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, United States.
Eric R GreeneDepartment of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, United States.ORCID 0000-0003-1717-0914

Funding

U-RISE at San Francisco State UniversityT34GM145400 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI Raymond M. Esquerra, MEGUMI M. FUSE · 2022 to 2026
$4.6M
NIGMS NIH HHS T34 GM145400
6 · The paper itself

Abstract

Glutamine synthetase (GS) is a ubiquitous enzyme central to nitrogen metabolism, catalyzing the ATP-dependent formation of glutamine from glutamate and ammonia. Positioned at the intersection of nitrogen metabolism with carbon metabolism, the activity of GS is subject to sophisticated regulation. While the intricate regulatory pathways that govern

Indexed as

Glutamate-Ammonia LigaseCryoelectron MicroscopyEscherichia coliKetoglutaric AcidsNitrogenGlutamate-Ammonia LigaseKetoglutaric AcidsNitrogen

Identifiers

PMID39844577
PMCPMC11800386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.