Evidence map›Paper›PMID 39844564›Full record

ArticleAnti-cancer agents in medicinal chemistry2025

Chlorogenic Acid Ameliorates CCl

Amr Negm, Amira Afifi El-Neanaey, Abada El Sayed Khadr, Maher Abd El Naby Kamel, Abd El-Hamid Abdo Ismail, Ibrahim El Tantawy El Sayed, Wael Sobhy Darwish, Mabrouk Attia Abd Eldaim, Raghda Sobhy Okaz, Mohamed Hamdy Bahr and 4 more

Abstract read
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Article in Anti-cancer agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amr NegmDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.ORCID 0000-0001-9801-3261
Amira Afifi El-NeanaeyChemistry Department, Faculty of Science, Menoufia University, Menoufia, 32511, Egypt.
Abada El Sayed KhadrChemistry Department, Faculty of Science, Menoufia University, Menoufia, 32511, Egypt.
Maher Abd El Naby KamelDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, 21516, Egypt.
Abd El-Hamid Abdo IsmailChemistry Department, Faculty of Science, Menoufia University, Menoufia, 32511, Egypt.
Ibrahim El Tantawy El SayedChemistry Department, Faculty of Science, Menoufia University, Menoufia, 32511, Egypt.
Wael Sobhy DarwishChemistry Department, Faculty of Science, Menoufia University, Menoufia, 32511, Egypt.
Mabrouk Attia Abd EldaimDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Menoufia University, 32511, Egypt.
Raghda Sobhy OkazDepartment of Medicine Vision College, Riyadh, Saudi Arabia.
Mohamed Hamdy BahrDepartment of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt.ORCID 0000-0002-0473-8163
Nihal AlmuraikhiStem cell unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia.
Nermine BesharaDepartment of Physiology, Neuroscience and Behavioral Sciences, St. George's University, School of Medicine, Grenada, West Indies.
Tamer Mohamed ShawkyDepartment of Anatomy and Embryology, Faculty of Medicine, Cairo University, Giza, Egypt.
Ezat A MersalDepartment of Basic Medical Sciences, Vision Colleges, Riyadh, 11451, Saudi Arabia.

Funding

Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia KFU250160King Saud University, Riyadh, Saudi Arabia RSP2025R471
6 · The paper itself

Abstract

backgroundLiver fibrosis represents a serious risk to global health by impairing quality of life and elevating the chances of hepatocellular carcinoma, while the intricate role of autophagy can either alleviate or worsen fibrosis depending on its functioning.

objectiveHerein, we aimed to investigate the therapeutic effect of chlorogenic acid in CCl

methodsRats were injected with carbon tetrachloride (1ml/kg) to induce liver fibrosis for 10 weeks. In the current study, the liver fibrosis rats were treated daily with chlorogenic acid (20, 40, and 60 mg/kg) for 30 days. Liver function tests, renal function tests, lipid peroxidation, antioxidant enzyme, anti-inflammatory NF-κB level, and autophagy pathway parameters (PI3K, AKT, mTOR, LC3, and Beclin-1) were assessed.

resultsCCl

conclusionChlorogenic acid showed promise in reducing liver damage in rats caused by CCl

Indexed as

AutophagyChlorogenic AcidLiver CirrhosisProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAnimalsCarbon TetrachlorideDose-Response Relationship, DrugMaleMolecular StructurePhosphatidylinositol 3-KinasesRatsRats, Sprague-DawleySignal TransductionStructure-Activity RelationshipCarbon TetrachlorideChlorogenic AcidmTOR protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesBeclin-1.CCl4Chlorogenic acidhepatic fibrosisLC3mTOR

Identifiers

PMID39844564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.