Evidence map›Paper›PMID 39844553›Full record

ArticleCurrent topics in medicinal chemistry2025

PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells.

Claudio Cesar Cirne-Santos, Daniel Tadeu Gomes Gonzaga, Gabriel Oliveira de Resende, Mariana de Castro Goncalves, Aymee da Silva Andrade, Paulo Anastacio Furtado Pacheco, Alexandre Dos Santos-Rodrigues, Vitor Won-Held Rabelo, Paula Alvarez Abreu, Robson Xavier Faria and 5 more

Abstract read
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Article in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Claudio Cesar Cirne-SantosUniversidade Federal Fluminense, Instituto de Biologia, Laboratório de Virologia Molecular e Biotecnologia Marinha, 24210-200, Niterói-RJ, Brasil.ORCID 0000-0001-8376-1830
Daniel Tadeu Gomes GonzagaUniversidade do Estado do Rio de Janeiro, FCBS, DEPFARM, Rio de Janeiro, Brasil.ORCID 0000-0002-3005-0610
Gabriel Oliveira de ResendeInstituto Oswaldo Cruz, Laboratório de Comunicação Celular, Fundação Oswaldo Cruz, RJ Brazil.ORCID 0000-0001-5048-8882
Mariana de Castro GoncalvesUniversidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, 24210-141, Niterói-RJ, Brasil.ORCID 0000-0003-0106-5589
Aymee da Silva AndradeUniversidade Federal Fluminense, Instituto de Biologia, Laboratório de Virologia Molecular e Biotecnologia Marinha, 24210-200, Niterói-RJ, Brasil.
Paulo Anastacio Furtado PachecoUniversidade Federal Fluminense, Instituto de Biologia, Departamento de Imunobiologia, Laboratório de Imunovirologia, 24210-200, Niterói-RJ, Brasil.
Alexandre Dos Santos-RodriguesUniversidade Federal Fluminense,Instituto de Biologia, Departamento de Neurobiologia, Programa de Pós-Graduação em Neurociências, Instituto de Biologia, Niterói, Brasil.
Vitor Won-Held RabeloUniversidade Federal Fluminense, Instituto de Biologia, Laboratório de Virologia Molecular e Biotecnologia Marinha, 24210-200, Niterói-RJ, Brasil.
Paula Alvarez AbreuUniversidade Federal do Rio de Janeiro, Instituto de Biodiversidade e Sustentabilidade, Macaé, RJ, CEP 27965-045, Brasil.
Robson Xavier FariaInstituto Oswaldo Cruz, Laboratório de Comunicação Celular, Fundação Oswaldo Cruz, RJ Brazil.ORCID 0000-0001-8218-834X
David Rodrigues da RochaUniversidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, 24210-141, Niterói-RJ, Brasil.ORCID 0000-0002-7928-8646
Fernando de Carvalho da SilvaUniversidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, 24210-141, Niterói-RJ, Brasil.
Vitor Francisco FerreiraUniversidade Federal Fluminense, Faculdade de Farmácia, Departamento de Tecnologia Farmacêutica, CEP 24241-000 Niterói, RJ, Brazil.
Caroline de Souza BarrosPrograma de Pós-graduação em Ciências e Biotecnologia (PPBI), Instituto de Biologia, Universidade Federal Fluminense, 24210-200, Niterói, RJ, Brasil.ORCID 0000-0002-4678-3093
Izabel Christina Nunes de Palmer PaixaoUniversidade Federal Fluminense, Instituto de Biologia, Laboratório de Virologia Molecular e Biotecnologia Marinha, 24210-200, Niterói-RJ, Brasil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 001FAPERJ (Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro) 26/211.556/2021-268667ICNPP 304070/2014-9ICNPP and VLT E-26/201.442/2014
6 · The paper itself

Abstract

backgroundZika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain- Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence and the resulting epidemics in 2016, the search for effective antiviral drugs has become absolutely necessary.

methodsIn this study, we examined the potential of naphthoquinone derivatives that have a sulfonamide or sulfonate group to inhibit ZIKV replication in primary cultured neurons and in Vero cells.

resultsIn our

conclusionThe ZIKV inhibitor described in this study shows promise as a compound for the development of therapies against ZIKV. It may also be considered for inclusion in the portfolio of broad-spectrum antiflavivirus inhibitors.

Indexed as

Antiviral AgentsNaphthoquinonesVirus ReplicationZika VirusAnimalsChlorocebus aethiopsDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMolecular StructureNeuronsStructure-Activity RelationshipVero CellsAntiviral AgentsNaphthoquinonesArbovirusNaphthoquinone; Antiviral; ZIKA-VirusNS2B-NS3.PAV05

Identifiers

PMID39844553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.