Evidence map›Paper›PMID 39844543›Full record

ReviewCurrent pharmaceutical design2025

Metabolic Tagging Technology of Exosomes-An Updated Review.

Aniruddha Sen, Palani Selvam Mohanraj, Srinivas Nagaram, Anita Samanta, Sumel Ashique, Anas Islam, Shriyansh Srivastava, Harpreet Singh, Arun Kumar Mishra, Shivani Chopra and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aniruddha SenDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh 273008, India.
Palani Selvam MohanrajDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh 273008, India.
Srinivas NagaramDepartment of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh 273008, India.
Anita SamantaDepartment of Allied Health, School of Health and Medical Sciences, Adamas University, Barasat, Kolkata 700126, India.
Sumel AshiqueDepartment of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
Anas IslamDepartment of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226026, India.
Shriyansh SrivastavaDepartment of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India.
Harpreet SinghSchool of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244102, India.
Arun Kumar MishraSOS School of Pharmacy, IFTM University, Moradabad, Uttar Pradesh 244102, India.
Shivani ChopraDepartment of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India.
Hitesh ChopraCentre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small extracellular vesicles secreted by various cell types, playing a crucial role in intercellular communication by carrying proteins, lipids, and nucleic acids, thus holding significant potential in diagnostics and therapeutics. Accurate labeling of exosomes is vital for studying their biogenesis, trafficking, and functional properties, enabling precise tracking and manipulation. This review examines current labeling techniques, including metabolic glycan labeling, chemical tagging, membrane fluorescent dyes, bio-conjugation, non-covalent labeling, and cell-engineering approaches. Each method is analyzed for its efficiency, specificity, and practicality, with attention to potential artifacts and challenges. Advancements in these techniques are essential for improving our understanding of exosome biology and developing exosome-based diagnostic and therapeutic strategies, providing researchers with valuable insights into state-of-the-art techniques and their applications in exosome research.

Indexed as

ExosomesStaining and LabelingAnimalsFluorescent DyesHumansFluorescent Dyesbio-conjugation.chemical taggingExosomesglycan labelingmembrane fluorescent dyesmetabolic labeling

Identifiers

PMID39844543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.