Evidence map›Paper›PMID 39844415›Full record

ReviewCurrent radiopharmaceuticals2025

Harnessing Radionuclides: Unveiling the Promising Role of Radiopharmaceuticals in Cancer Theranostics and Palliative Care.

Mihai Cozmin, Ionut Iulian Lungu, Radu Cernei, George Alexandru Marin, Letitia Doina Duceac, Gabriela Calin, Marius Gabriel Dabija, Cristian Gutu, Elena Roxana Bogdan Goroftei, Alina Stefanache and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current radiopharmaceuticals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mihai CozminFaculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.
Ionut Iulian LunguDepartment of Inorganic Chemistry, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Radu CerneiDepartment of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
George Alexandru MarinDepartment of Chemistry, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Letitia Doina DuceacFaculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.
Gabriela CalinFaculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.
Marius Gabriel DabijaDepartment of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Cristian GutuFaculty of Medicine and Pharmacy University Dunarea de Jos, 47 Domneasca Str., 800008, Galati, Romania.
Elena Roxana Bogdan GorofteiFaculty of Medicine and Pharmacy University Dunarea de Jos, 47 Domneasca Str., 800008, Galati, Romania.
Alina StefanacheDepartment of Inorganic Chemistry, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Tudor CiuhodaruFaculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn the context of modern oncology, radiogenic elements have emerged as pivotal tools for targeted cancer therapies. Elements like Iodine-131 and Yttrium-90 offer unique radiological properties that allow precise treatment delivery. This article explores their growing importance and potential in reshaping the landscape of cancer therapy.

methodsUtilizing a systematic literature search, relevant studies, clinical trials, and research articles were collected from databases. The selected material was scrutinized to extract insights into the mechanisms, applications, advantages, and challenges of radiogenic elements. These results are combined in the study to give a perceptive picture of how contemporary oncology treatment is developing.

resultsThe article reveals a comprehensive analysis of the outcomes derived from the study of radiogenic elements in contemporary cancer treatment. The results highlight the diverse applications of radionuclides like Iodine-131, Yttrium-90, and actinides in targeted therapies. It showcases their ability to selectively damage cancer cells while sparing healthy tissues, emphasizing precision and efficacy. The review underscores the increasing importance of personalized medicine, combination therapies, and the potential of emerging alpha-particle-based treatments. Furthermore, the results shed light on the challenges posed by radiation safety and potential side effects, prompting a need for vigilant management. This comprehensive examination of results provides a nuanced understanding of the pivotal role that radiogenic elements play in shaping the future of modern oncology therapy.

conclusionThe article examines the role of radiogenic elements in contemporary cancer treatment. It highlights the significance of elements like 131I, 90Y, and actinides in targeted therapies, discussing their mechanisms and applications. The article emphasizes personalized medicine, combination therapies, and emerging alpha-particle-based treatments. Challenges, including radiation safety and side effects, are also addressed. The review anticipates a promising future where radiogenic elements contribute to precise, effective, and patient-centered cancer care.

Indexed as

NeoplasmsPalliative CareRadiopharmaceuticalsHumansIodine RadioisotopesPrecision MedicineTheranostic NanomedicineYttrium RadioisotopesIodine-131Iodine RadioisotopesRadiopharmaceuticalsYttrium-90Yttrium Radioisotopesactinides.cancer treatmentIodine-131modern oncology therapyRadiogenic elementsYttrium-90

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.