Evidence map›Paper›PMID 39844414›Full record

ArticleCurrent organic synthesis2025

Synthesis, Molecular Docking, Antimicrobial, and Antioxidant Evaluation of Novel Dithiazole and Thiazole Derivatives.

Rizk E Khidre, Eman Sabry, Ashraf A Sediek, Ahmed F El-Sayed

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Article in Current organic synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rizk E KhidreChemical Industries Institute, National Research Centre, Dokki, 12622, Giza, Egypt.ORCID 0000-0002-2317-8683
Eman SabryChemical Industries Institute, National Research Centre, Dokki, 12622, Giza, Egypt.
Ashraf A SediekChemical Industries Institute, National Research Centre, Dokki, 12622, Giza, Egypt.
Ahmed F El-SayedMicrobial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Funding

National Research Centre, Dokki, Cairo, Egypt 13010106
6 · The paper itself

Abstract

introductionAn efficient procedure was reported for the synthesis of novel hybrid dithiazoles 7 and thiazoles 15, in good yields, by applying hydrazonyl chlorides 4 with thiocarbohydrazone derivatives 3 and 12.

methodsThe thiazole derivatives were evaluated for their antimicrobial and antioxidant activities.

resultsAccording to the results, thiazoles revealed marked potency as antimicrobial and antioxidant agents. Thus, 7a's DPPH radical scavenging activity was excellent (38.19±0.33 and 14.37±0.4) at concentrations of 2.0 and 1.0 mg/mL, respectively. In addition, compound 3 exhibited activity against all bacterial strains tested, as evidenced by inhibition zones measuring that ranged from 8.5±0.43 mm for

conclusionThe MIC results showed that compound 3 was effective against

Indexed as

Anti-Bacterial AgentsAntioxidantsMolecular Docking SimulationThiazolesEscherichia coliMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntioxidantsThiazolesADMEantimicrobial activityantioxidant activity.dockinghydrazonyl chloridesSynthesisthiazole

Identifiers

PMID39844414

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.