Evidence map›Paper›PMID 39844403›Full record

ArticleCurrent neuropharmacology2025

Modulation of

Fei Ran Li, Maxime Lévesque, Siyan Wang, Mia Gemayel, Massimo Avoli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fei Ran LiDepartments of Neurology & Neurosurgery, and Physiology, Montreal Neurological Institute-Hospital, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.
Maxime LévesqueDepartments of Neurology & Neurosurgery, and Physiology, Montreal Neurological Institute-Hospital, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.
Siyan WangDepartments of Neurology & Neurosurgery, and Physiology, Montreal Neurological Institute-Hospital, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.
Mia GemayelDepartment of Psychology, McGill University, 2001 McGill College, Montreal, Quebec, H3A 1G1, Canada.
Massimo AvoliDepartments of Neurology & Neurosurgery, and Physiology, Montreal Neurological Institute-Hospital, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.

Funding

CIHR PJT153310, PJT166178, MOP130328
6 · The paper itself

Abstract

backgroundCatamenial epilepsy, which is defined as a periodicity of seizure exacerbation occurring during the menstrual cycle, has been reported in up to 70% of epileptic women. These seizures are often non-responsive to medication and our understanding of the relation between menstrual cycle and seizure generation (i.e. ictogenesis) remains limited.

methodsHere, we employed the

resultsWe found that: (i) optogenetic stimulation of PV-positive interneurons induced an initial interictal spike followed by field oscillations occurring more often in estrous (59%) than in non-estrous slices (17%); (ii) these oscillations showed significantly higher power in estrous compared to nonestrous slices (p < 0.001); (iii) significantly higher rates of interictal spikes and ictal discharges were identified in both estrous and non-estrous slices during optogenetic stimulation of PV-positive interneurons compared to periods of no stimulation (p < 0.05); and (iv) ictal events appeared to occur more frequently during optogenetic stimulation in estrous compared to non-estrous slices.

conclusionOur findings show that optogenetic activation of PV-interneurons leads to more powerful network oscillations and more frequent ictal discharges in estrous than in non-estrous slices. We conclude that during the rodent estrous cycle, PV-interneuron hyperexcitability may play a role in epileptiform synchronization and thus in catamenial seizures.

Indexed as

Estrous CycleInterneuronsNerve NetOptogeneticsParvalbuminsAction PotentialsAnimalsFemaleMiceMice, Inbred C57BLMice, TransgenicParvalbumins4-aminopyridineCatamenial epilepsyestrous cyclesoptogenetic stimulationparvalbumin-positive interneuronsprogesterone blood levels.

Identifiers

PMID39844403
PMCPMC12163479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.