Evidence map›Paper›PMID 39844354›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study.

Mandy Fisher, Graeme Smith, Beth K Potter, Tye E Arbuckle, Julian Little, Hope Weiler, Anne-Sophie Morisset, Bruce Lanphear, Joseph M Braun, Premkumari Kumarathasan and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mandy FisherEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.ORCID 0000-0003-4656-3813
Graeme SmithDepartment of Obstetrics and Gynaecology, Queen's University, Kingston, ON, Canada K7L 2V7.ORCID 0000-0002-3128-4523
Beth K PotterSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada K1G 5Z3.
Tye E ArbuckleEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.
Julian LittleSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada K1G 5Z3.ORCID 0000-0001-5026-5531
Hope WeilerNutrition Research Division, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
Anne-Sophie MorissetSchool of Nutrition, Laval University, Québec City, QC, Canada G1V 0A6.ORCID 0000-0002-9214-8912
Bruce LanphearSimon Fraser University, Vancouver, BC, Canada V4A 1S6.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI 02903, USA.
Premkumari KumarathasanEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.
Mark WalkerDepartment of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada K1H 8L6.ORCID 0000-0001-8974-4548
Michael M BorgheseEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.
Jillian Ashley-MartinEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.ORCID 0000-0001-9958-7531
Robin ShuttEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.
Linda DoddsDepartments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, Halifax, NS, Canada B3K 6R8.
Jennifer E BruinDepartment of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada K1S 5B6.
Jana PalaniyandiEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada K1A 0K9.
Michael HelewaDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, St. Boniface Hospital, Winnipeg, MB, Canada R2H 2A6.
Shayne TabackFaculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada R3E 3P5.
Isabelle MassarelliNutrition Research Division, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
Mark R PalmertDivision of Endocrinology, Departments of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8.ORCID 0000-0002-4096-0685
John KrzeczkowskiDepartment of Health Sciences, Brock University, St. Catherines, ON, Canada L2S 3A1.
William D FraserCentre de Recherche du CHUS and Department of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4.

Funding

Health Canada's Chemicals Management Plan
6 · The paper itself

Abstract

contextDuring pregnancy, women who experience certain pregnancy complications show elevations in biomarkers of inflammation and insulin resistance; however, few studies have examined these cardiometabolic biomarkers in the decade following pregnancy.

objectiveTo examine the association between pregnancy complications and cardiometabolic biomarkers 9 years postpartum including blood pressure, blood lipids, body fat percentage, insulin resistance [glucose, insulin, proinsulin, C-peptide, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), glycated hemoglobin (HbA1c), leptin, adiponectin], and inflammation (high-sensitivity-C-reactive protein).

methodsUsing data from the Maternal-Infant Research on Environmental Chemicals cohort study (2008-2021), we determined 3 groups of pregnancy complications: (1) hypertensive disorders of pregnancy (HDP) (n = 35); (2) any pregnancy complication in the index pregnancy, defined as preterm birth, HDP, impaired glucose tolerance or gestational diabetes mellitus (n = 55); and (3) self-reported recurrence of 1 of these pregnancy complications (n = 19). Our comparison group included 186 women with uncomplicated pregnancies.

resultsIn our adjusted linear regression results, all pregnancy complication groups showed significantly higher systolic and diastolic blood pressure 9 years later. HOMA-IR was 23% [95% confidence interval (CI): -4.4%, 57%], 26% (95% CI: 2.0%, 55%), and 51% (95% CI: 12%, 104%) higher at follow-up in participants who had experienced a prior HDP, an index pregnancy complication, or a recurrent pregnancy complication, respectively. Elevations were also seen with HbA1c, insulin, C-peptide, and leptin, especially among those with recurrent complications.

conclusionThis study contributes to the body of evidence that women with a history of certain pregnancy complications merit special attention in the prevention of cardiovascular disease. We recommend further exploration into these associations in larger cohorts.

Indexed as

BiomarkersInsulin ResistanceMaternal HealthPregnancy ComplicationsAdultBlood GlucoseBlood PressureCohort StudiesDiabetes, GestationalFemaleFollow-Up StudiesGlycated HemoglobinHumansHypertension, Pregnancy-InducedPostpartum PeriodPregnancyBiomarkersBlood GlucoseGlycated Hemoglobincardiometabolic healthhypertensive disorderspregnancyrecurrence

Identifiers

PMID39844354
PMCPMC12448617

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.