Evidence map›Paper›PMID 39844334›Full record

ArticleTrials2025

A single-site randomized controlled trial of partner navigation to HCV treatment for people who inject drugs: a study protocol for the You're Empowered for Treatment Initiation (YETI) partner trial.

Meghan D Morris, Judy Y Tan, Claire C McDonell, Maia Scarpetta, Tiffany N Nguyen, Jennifer C Price, Torsten B Neilands

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06179498 (A Randomized Trial to Test the Efficacy of a Partner Navigation Intervention for HCV Treatment Among Young Adult People Who Inject Drugs), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06179498 narecruitingnot on this map

A Randomized Trial to Test the Efficacy of a Partner Navigation Intervention for HCV Treatment Among Young Adult People Who Inject Drugs

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled500ConditionsHepatitis CArmsPartner Navigation Intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meghan D MorrisDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA. Meghan.Morris@ucsf.edu.ORCID http://orcid.org/0000-0003-2762-2953
Judy Y TanCancer Research Center for Health Equity, Division of Population Sciences, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA.
Claire C McDonellDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA.
Maia ScarpettaDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA.
Tiffany N NguyenDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA.
Jennifer C PriceDepartment of Medicine, University of California, San Francisco, USA.
Torsten B NeilandsCenter for AIDS Prevention Sciences, Division of Prevention Science, University of California, San Francisco, USA.

Funding

The Impact of Stigma on Interpersonal Relationships of Young Adult People who Inject DrugsR01DA053325 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Meghan D Morris · 2022 to 2026
$3.7M
NIDA NIH HHS R01 DA053325
6 · The paper itself

Abstract

backgroundDisparities persist in testing and treatment for hepatitis C virus (HCV), leaving socially marginalized populations, including people who inject drugs (PWID), less likely to benefit from curative treatment. Linkage services are often insufficient to overcome barriers to navigating the medical system and contextual factors.

methodsThe You're Empowered for Treatment Initiation (YETI) Partner trial is a single-site randomized controlled trial evaluating the efficacy of a two-session behavioral intervention that engages injecting partners as peer navigators for HCV treatment. We aim to recruit 250 PWID and their primary injecting partners in San Francisco, California, randomizing them 1:1 to either a control or intervention group. The primary outcome is the initiation of HCV treatment, with secondary outcomes including treatment completion and sustained virologic response 12 weeks post-treatment. Data will be collected through questionnaires and electronic health records and analyzed using intention-to-treat and mixed-effects models. DISCUSSION: This trial will provide evidence of a new HCV treatment linkage intervention leveraging the support of primary injecting partners to initiate HCV treatment. If successful, the intervention could inform public health strategies and policies to address HCV in marginalized populations.

trial registrationClinicalTrials.gov NCT06179498. Registered on December 22, 2023.

Indexed as

Drug UsersHepatitis CPatient NavigationSubstance Abuse, IntravenousFemaleHumansMaleRandomized Controlled Trials as TopicSan FranciscoSustained Virologic ResponseTime FactorsTreatment OutcomeClinical trialDyad interventionHCVHCV treatmentHepatitis CPartner supportPeople who inject drugsRandomized trial

Identifiers

PMID39844334
PMCPMC11753105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.