ArticleCardiovascular diabetology2025
Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Association between eGDR and the risk of chest pain: A comparative analysis based on NHANES and CHARLS databases.Medicine · 2026Article
- Combined associations of the metabolic score for insulin resistance and estimated glucose disposal rate with cardio-renal-metabolic multimorbidity: evidence from two large population studies.BMC cardiovascular disorders · 2026Article
- Association between insulin resistance surrogate markers and cardiovascular disease risk in individuals with subclinical metabolic disorders: a prospective cohort study based on baseline levels, cumulative exposure, and longitudinal trajectories.Cardiovascular diabetology · 2026Article
- Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.Health science reports · 2026Article
- Glucose Disposal Rate: A Novel Measure of Insulin Resistance Associated With Myocardial Fibrosis and Incident Heart Failure.Journal of the American Heart Association · 2026Article
- Association between estimated glucose disposal rate and sarcopenia in U.S. adults: a cross-sectional study based on NHANES 2011-2018.Diabetology & metabolic syndrome · 2026Article
- Association between dietary inflammatory index and depression in individuals with cardiovascular-kidney-metabolic syndrome stage 0-3: a cross-sectional study.Diabetology & metabolic syndrome · 2026Article
- Article
- Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in metabolic-dysfunction associated steatotic liver disease: evidence from two cohort studies.Cardiovascular diabetology · 2026Observational
- Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults.Cardiovascular diabetology · 2026Article
- Association between estimated glucose disposal rate and incident heart failure in patients with coronary heart disease: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Prognostic effect of estimated glucose disposal rate on all-cause and cardiovascular mortality among individuals cardiovascular-kidney-metabolic syndrome.Diabetology & metabolic syndrome · 2026Article
- Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis.Cardiovascular diabetology · 2026Article
- Association of the estimated glucose disposal rate combined with a body shape index with all-cause and cardiovascular-specific mortality among individuals with cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Association between estimated glucose disposal rate and heart disease events in adults with overweight or obesity: a prospective cohort study.Journal of translational medicine · 2026Article
- Estimated glucose disposal rate and cardiovascular risk in metabolically healthy adults: a nationwide prospective cohort study.Scientific reports · 2026Article
- Association of weekday sleep duration and estimated glucose disposal rate: the role of weekend catch-up sleep.BMJ open diabetes research & care · 2026Article
- Joint association of estimated glucose disposal rate and aggregate index of systemic inflammation with mortality in general population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Estimated glucose disposal rate is associated with brain aging and dementia among diabetes-free older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study.Therapeutic advances in endocrinology and metabolism · 2026Article
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3 authors.
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Abstract
backgroundInsulin resistance (IR) is a central pathophysiological factor in metabolic syndrome (MetS) and an essential driver of cardiovascular disease (CVD) and mortality. The estimated glucose disposal rate (eGDR) is a reliable marker of IR and has been associated with CVD prognosis. This study aims to examine the relationship between eGDR, MetS, and their predictive roles in clinical outcomes.
methodsData from the NHANES (2001-2018) were utilized, with a cross-sectional design applied to evaluate the association between eGDR and MetS prevalence, and a cohort design employed for mortality follow-up. Weighted logistic regression models were used to examine the association between eGDR and MetS. Weighted Cox proportional hazard models were applied to assess the link between eGDR and both all-cause and CVD mortality. To examine the non-linear associations between the eGDR, MetS, and mortality outcomes, restricted cubic spline (RCS) analysis was applied. Additionally, the predictive performance of eGDR, and other IR indices (TyG, HOMA-IR), for mortality was assessed using the C-statistic.
resultsA robust negative association between eGDR and MetS prevalence was found, following full covariate adjustment (p < 0.001). The core findings were consistent across subgroups (all p < 0.001). Cox regression analysis indicated that in individuals with MetS, each standard deviation (SD) increment in eGDR was associated with an 11% and 18% decrement in the risk of all-cause and CVD mortality, respectively. RCS analysis displayed a non-linear association between eGDR and MetS prevalence, while a linear association between eGDR and mortality. The C-statistic showed that eGDR, compared to the TyG index and HOMA-IR, significantly improved predictive power for all-cause mortality (p = 0.007).
conclusioneGDR is strongly associated with MetS and predicts all-cause and CVD mortality in individuals with MetS. Compared to TyG and HOMA-IR, eGDR offers superior predictive value for all-cause mortality, highlighting its potential as a useful tool in clinical risk assessment.
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