Trial reportBMC pregnancy and childbirth2025
Restless legs syndrome without insomnia and antenatal depressive symptoms.
Trial report in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Time-varying restless legs syndrome and risk of incident perinatal depression.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundRestless legs syndrome (RLS) with insomnia is presumed to be associated with antenatal depression. RLS without insomnia, however, has not been investigated in association with antenatal depression. We aimed to examine whether RLS without insomnia during pregnancy is associated with antenatal depressive symptoms.
methodsThis cross-sectional study used data from a randomized controlled trial (RCT) assessing antenatal depressive symptoms among Japanese pregnant women. The participants were 2,108 women who attended the RCT at 16-20 weeks of pregnancy. RLS, insomnia, and antenatal depressive symptoms were assessed using the Cambridge-Hopkins questionnaire short form, Insomnia Severity Index, and Edinburgh Postnatal Depression Scale, respectively. Associations of antenatal depressive symptoms with RLS and insomnia were examined using logistic regression analysis, adjusting for age, partner, education, children, and planned pregnancy.
resultsOf the total participants, 206 (9.8%) had antenatal depressive symptoms; 80 (3.8%) had RLS. The mean age (standard deviation) was 30.4 (4.6) years. RLS was positively associated with antenatal depressive symptoms: the odds ratio was 2.30 (95% confidence interval, 1.28-4.16). RLS without insomnia was positively associated with antenatal depressive symptoms, as well as insomnia without RLS and RLS with insomnia: the odds ratio was 2.44 (95% confidence interval, 1.09-5.46) for RLS without insomnia, 3.83 (2.78-5.28) for insomnia without RLS, and 5.80 (2.42-13.92) for RLS with insomnia, compared to neither RLS nor insomnia.
conclusionsWe observed the positive association between RLS without insomnia and antenatal depressive symptoms, suggesting the importance of assessing and treating RLS without insomnia during pregnancy for the reduction of antenatal depressive symptoms.
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