ArticleScientific reports2025
Analysis of retinal sublayers in patients with systemic COVID-19 illness with varying degrees of severity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Subclinical neurovascular and immune correlates of post-COVID-19 syndrome detected by retinal imaging.Brain, behavior, & immunity - health · 2026Article
- Neuroretinal Alterations in Persistent COVID-19: A Two-Year OCT Follow-Up.Journal of clinical medicine · 2026Article
- Long-term retinal dysfunction following COVID-19 infection: a one-year prospective observational study.BMC ophthalmology · 2026Observational
- Optical Coherence Tomography (OCT) Findings in Post-COVID-19 Healthcare Workers.Journal of imaging · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 infection has been linked to ocular involvement, particularly retinal microvascular changes. Additionally, prolonged hypoxemia may affect retinal sublayers located within the retinal watershed zone. The aim of this study was to evaluate retinal and optic nerve OCT parameters in patients with COVID-19 illness of varying severity and compare them with controls. In this prospective case-control study, a total of 78 consecutive patients who had recently recovered from SARS-CoV-2 infection (29 outpatients, 32 ward-admitted patients, and 17 ICU-admitted patients) were included, along with 85 controls. All participants had no ocular disease or symptoms. Spectralis SD-OCT scans of the macula and optic nerve were obtained from all participants 6 weeks after initial diagnosis. The central subfield thickness of the macula (CSFT), peripapillary retinal nerve fiber layer thickness (pRNFL), and retinal sublayers' volumes in the total 6-mm ETDRS zone were recorded and analyzed using the ANCOVA test, adjusting for age. The mean CSFT in controls was 271 μm, while in the outpatient, ward-admitted, and ICU-admitted groups, it was 251, 260, and 253 μm, respectively (P = 0.093). No differences were observed in pRNFL between the groups (P> 0.1). However, the outer plexiform layer (OPL) was the only retinal sublayer that demonstrated a significant difference in 6-mm volume across the groups, with volumes of 0.832 μm
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