ArticleDigestive diseases and sciences2025
Maternal Smoking Around Birth Is a Risk Factor for Gastrointestinal Diseases in Offspring: A Mendelian Randomization Study.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe effect of maternal smoking around birth (MSAB) on gastrointestinal (GI) diseases in the offspring is still not fully understood.
aimWe conducted a rigorous Mendelian randomization (MR) study to examine the association between MSAB and 24 GI diseases in offspring.
methodsSingle nucleotide polymorphisms (SNPs) associated with MSAB were obtained from a recent study. SNPs of GI diseases were all from the FinnGen project. We performed two-sample MR analyses (TSMR) using three methods, predominantly the inverse variance weighting (IVW) method. We performed sensitivity analyses and false discovery rate (FDR) to confirm the accuracy and robustness of the results.
resultsGenetically determined MSAB significantly influenced offspring GI diseases according to the IVW method (OR 1.251; 95% CI 1.111-1.408; P = 2.111e-04; P
conclusionsThis comprehensive TSMR analysis demonstrated that genetically predicted MSAB is a risk factor for GI disorders, including IBD, UC, and peptic ulcer, in offspring. Individuals whose mothers smoked during pregnancy are subject to increased health surveillance for GI diseases. And we need more research to explore the mediating mechanisms involved.
Indexed as
Identifiers
39843788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.