Evidence map›Paper›PMID 39843784›Full record

SynthesisStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025

Multidisciplinary treatment is necessary in glioblastoma with extracerebral metastases.

Niklas B Pepper, David R Steike, Heidi Yppärilä-Wolters, Michael Müther, Dorothee Wiewrodt, Hendrik Berssenbrügge, Oliver Grauer, Philipp Lenz, Walter Stummer, Hans T Eich

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niklas B PepperDepartment of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany. Niklas.pepper@ukmuenster.de.ORCID 0000-0002-5917-4203
David R SteikeDepartment of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.
Heidi Yppärilä-WoltersDepartment of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.
Michael MütherDepartment of Neurosurgery, University Hospital Muenster, Muenster, Germany.
Dorothee WiewrodtDepartment of Neurosurgery, University Hospital Muenster, Muenster, Germany.
Hendrik BerssenbrüggeDepartment of ear, nose and throat medicine, University Hospital Muenster, Muenster, Germany.
Oliver GrauerDepartment of Neurology with Institute of Translation Neurology, University Hospital Muenster, Muenster, Germany.
Philipp LenzDepartment of Palliative Care, University Hospital Muenster, Muenster, Germany.
Walter StummerDepartment of Neurosurgery, University Hospital Muenster, Muenster, Germany.
Hans T EichDepartment of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWhile glioblastoma is the most common malignant brain tumor in adults, extracerebral manifestations are very rare in this highly aggressive disease with poor prognosis.

methodsWe conducted a systematic literature review in the PubMed database and complemented the data by inclusion of a case treated in our clinic. In this context, we report on a 60-year-old woman with a right frontal glioblastoma, IDH wildtype, MGMT methylated.

resultsSix months after initial diagnosis and primary treatment, there was extensive local intracranial progression with additional extension into the subcutaneous and frontotemporal cranial bones. Despite continuation of multimodal treatment, further extracerebral manifestations occurred 11 months after the initial diagnosis, both in the cranial bone as well as metastases in the right parotid gland, cervical lymph nodes, and lungs. While local radiotherapy enabled the cerebral lesions to be controlled, the patient's clinical condition deteriorated rapidly despite simultaneous systemic therapy. The treatment had to be discontinued, and the patient died 5 weeks after confirmation of the multilocal extracerebral manifestations and a total of 12 months after initial diagnosis.

conclusionExtracerebral manifestations of glioblastoma require close collaboration and joint decision-making with the patient, with an emphasis on palliative strategies.

Indexed as

Brain NeoplasmsGlioblastomaInterdisciplinary CommunicationLung NeoplasmsCombined Modality TherapyFatal OutcomeFemaleHumansIntersectoral CollaborationMiddle AgedPalliative CareParotid NeoplasmsExtra-axial manifestationHigh-grade gliomaPalliative careRadiochemotherapyRadiotherapy

Identifiers

PMID39843784
PMCPMC11928418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.