Evidence map›Paper›PMID 39843746›Full record

ArticleNature2025

Mapping cells through time and space with moscot.

Dominik Klein, Giovanni Palla, Marius Lange, Michal Klein, Zoe Piran, Manuel Gander, Laetitia Meng-Papaxanthos, Michael Sterr, Lama Saber, Changying Jing and 10 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Predictive control of human pancreatic cell fate using a digital model ofbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Charting Endocrine Progenitors Across Species and Organs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Single-cell analysis of microglia and monocyte dynamics uncovers distinct TNF-driven neuroimmune signatures in humans after intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  18. Review
  19. Review
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Dominik Klein *Institute of Computational Biology, Helmholtz Center, Munich, Germany.ORCID 0000-0002-7334-3501
Giovanni Palla *Institute of Computational Biology, Helmholtz Center, Munich, Germany.
Marius Lange *Institute of Computational Biology, Helmholtz Center, Munich, Germany.ORCID 0000-0002-4846-1266
Michal Klein *Apple, Paris, France.
Zoe Piran *School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0003-0241-8948
Manuel GanderInstitute of Computational Biology, Helmholtz Center, Munich, Germany.
Laetitia Meng-PapaxanthosGoogle DeepMind, Zurich, Switzerland.
Michael SterrInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.
Lama SaberInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.ORCID 0009-0004-0297-050X
Changying JingInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.ORCID 0000-0002-0671-4114
Aimée Bastidas-PonceInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.
Perla CotaInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.
Marta Tarquis-MedinaInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.
Shrey ParikhInstitute of Computational Biology, Helmholtz Center, Munich, Germany.
Ilan GoldInstitute of Computational Biology, Helmholtz Center, Munich, Germany.
Heiko LickertInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany. heiko.lickert@helmholtz-munich.de.ORCID 0000-0002-4597-8825
Mostafa BakhtiInstitute of Diabetes and Regeneration Research, Helmholtz Center, Munich, Germany.ORCID 0000-0002-2307-1122
Mor NitzanSchool of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0003-0074-9196
Marco CuturiApple, Paris, France.
Fabian J TheisInstitute of Computational Biology, Helmholtz Center, Munich, Germany. fabian.theis@helmholtz-munich.de.ORCID 0000-0002-2419-1943

Funding

Wellcome Trust
6 · The paper itself

Abstract

Single-cell genomic technologies enable the multimodal profiling of millions of cells across temporal and spatial dimensions. However, experimental limitations hinder the comprehensive measurement of cells under native temporal dynamics and in their native spatial tissue niche. Optimal transport has emerged as a powerful tool to address these constraints and has facilitated the recovery of the original cellular context

Indexed as

GenomicsSingle-Cell AnalysisSpatio-Temporal AnalysisAnimalsBrainCell LineageEmbryo, MammalianEmbryonic DevelopmentFemaleGene Expression ProfilingHumansLiverMaleMiceTranscriptome

Identifiers

PMID39843746
PMCPMC11864987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.