ArticleNature2025
RELMβ sets the threshold for microbiome-dependent oral tolerance.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance.Science translational medicine · 2026Article
- Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut.Nature reviews. Gastroenterology & hepatology · 2026Review
- Early-life Gut Microbiota and Allergic Diseases: Immune Regulatory Mechanisms and Intervention Progress.Clinical reviews in allergy & immunology · 2026Review
- Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity.Current opinion in immunology · 2026Review
- Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy.Experimental & molecular medicine · 2026Review
- [Research progress on the multidimensional regulation of gut microbiota on metabolism, immunity, and inflammatory response in metabolic associated fatty liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Review
- Lactobacilli biology, applications and host interactions.Nature reviews. Microbiology · 2026Review
- Context-dependent roles of resistin-like molecule β in mucosal defense and inflammatory diseases.Frontiers in immunology · 2026Review
- FOXP3 Stability-Adaptation Paradox: Reshaping Treg-Based Therapies for Intestinal Diseases.International journal of biological sciences · 2026Review
- Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization.Gut microbes · 2025Review
- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Microbiome in heritage: how maternal microbiome transmission impacts next generation health.Microbiome · 2025Review
- Thetis cells: regulators of intestinal immune tolerance.Current opinion in immunology · 2025Review
- Immune tolerance to foreign antigens in the intestine: mechanisms mediated by CD4＋ T cells.BMB reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Emmanuel Stephen-Victor *Division of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-5049-7017
Gavin A Kuziel *Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2338-0176
Monica Martinez-BlancoDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Bat-Erdene JugderDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Mehdi BenamarDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-1532-8642
Ziwei WangDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Qian ChenDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Gabriel L LozanoDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Azza Abdel-GadirDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Ye CuiDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Jason FongDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6164-6110
Elisa Saint-DenisDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Iris ChangDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA, USA.
Kari C NadeauDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-2146-2955
Wanda PhipatanakulDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Angela ZhangDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Farida Abi FarrajDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Faye Holder-NilesDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Daniel ZeveDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
David T BreaultDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0402-4857
Klaus Schmitz-AbeDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Rima RachidDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Elena CrestaniDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-7718-0431
Seth Rakoff-Nahoum *Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. seth.rakoff-nahoum@childrens.harvard.edu.ORCID 0000-0002-3233-0675
Talal A Chatila *Division of Immunology, Boston Children's Hospital, Boston, MA, USA. talal.chatila@childrens.harvard.edu.ORCID 0000-0001-7439-2762
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Scott B Snapper · 1986 to 2026
$32.4MMolecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9MEffect of IL-4RαR576 variant on response to Dupilumab in children with AsthmaU01AI143514 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, PHIPATANAKUL, WANDA · 2019 to 2023
$8.4MImmunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9MProgrammable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiomeR01AI171100 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KHALIL, AHMAD SAMIR, RAKOFF-NAHOUM, SETH · 2022 to 2025
$4.1MTargeting microbial dysbiosis in Food Allergy to restore toleranceR01AI158814 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, RAKOFF-NAHOUM, SETH · 2021 to 2025
$3.0MNovel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s HospitalU01AI160087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, WANDA PHIPATANAKUL · 2021 to 2026
$2.8MPositive Selection as a Host Mechanism to Control the MicrobiomeDP2GM136652 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI RAKOFF-NAHOUM, SETH · 2019 to 2019
$2.7MFunction of RELMβ in oral tolerance breakdown in food allergyK23AI155940 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CRESTANI, ELENA · 2021 to 2025
$975kMechanisms mediating human enteroendocrine cell differentiation and functionK08DK134885 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Daniel Richard Zeve · 2023 to 2026
$673kNIAID NIH HHS K23 AI155940NIAID NIH HHS R01 AI065617NIAID NIH HHS R01 AI126915NIAID NIH HHS R01 AI158814NIAID NIH HHS R01 AI171100NIAID NIH HHS U01 AI143514NIAID NIH HHS U01 AI160087NIDDK NIH HHS K08 DK134885NIDDK NIH HHS P30 DK034854NIGMS NIH HHS DP2 GM136652
Abstract
Tolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis
Indexed as
Food HypersensitivityGastrointestinal MicrobiomeImmune ToleranceAdministration, OralAnimalsDisease Models, AnimalFemaleHumansImmunoglobulin EIndolesLactobacillusMaleMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3Receptors, Aryl HydrocarbonImmunoglobulin EIndolesNuclear Receptor Subfamily 1, Group F, Member 3Receptors, Aryl Hydrocarbon
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.