Evidence map›Paper›PMID 39843710›Full record

ArticleCellular and molecular life sciences : CMLS2025

Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures.

Erlend Ravlo, Aleksandr Ianevski, Jørn-Ove Schjølberg, Vanessa Solvang, Rabina Dumaru, Hilde Lysvand, Jacqueline Hankinson, Markus Vähä-Koskela, Sanna Vainionpää, Anni Varhe and 21 more

Abstract read
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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Erlend Ravlo *Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Aleksandr Ianevski *Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Jørn-Ove SchjølbergDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Vanessa SolvangDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Rabina DumaruDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Hilde LysvandDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Jacqueline HankinsonDepartment of Pathology, University of Cambridge, Cambridge, CB21QP, UK.
Markus Vähä-KoskelaInstitute for Molecular Medicine FIMM, Helsinki Institute for Life Science, University of Helsinki, Helsinki, 00014, Finland.
Sanna VainionpääTranslational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Anni VarheTranslational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Hanna SeppänenTranslational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Teemu SmuraDepartment of Virology, University of Helsinki, Helsinki, 00014, Finland.
Xin WangDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, 3015, Netherlands.
Yining WangDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, 3015, Netherlands.
Pengfei LiDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, 3015, Netherlands.
Qiuwei PanDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, 3015, Netherlands.
Knut Dahl-JorgensenFaculty of Medicine, University of Oslo, Oslo, 0318, Norway.
Lars KrogvoldDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, 0424, Norway.
Oleksandr KamyshnyiDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, 46001, Ukraine.
Hans-Johnny Schjelderup NilsenDepartment of Medical Microbiology, Clinic for Laboratory Medicine, St. Olavs Hospital, Trondheim, 7028, Norway.
Inger Johanne HaugenDepartment of Medical Microbiology, Clinic for Laboratory Medicine, St. Olavs Hospital, Trondheim, 7028, Norway.
Erling HøyerDepartment of Medical Microbiology, Clinic for Laboratory Medicine, St. Olavs Hospital, Trondheim, 7028, Norway.
Jan Egil AfsetDepartment of Medical Microbiology, Clinic for Laboratory Medicine, St. Olavs Hospital, Trondheim, 7028, Norway.
Valentyn OksenychBroegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Angel S GalabovThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria.
Adelina StoyanovaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria.
Vivian LamLHL, Jessheim, 2067, Norway.
Barbara van LoonDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway.
Valeria LullaDepartment of Pathology, University of Cambridge, Cambridge, CB21QP, UK.
Magnar BjøråsDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway. magnar.bjoras@ntnu.no.
Denis E KainovDepartment of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, 7028, Norway. denis.kainov@ntnu.no.ORCID http://orcid.org/0000-0001-7716-6955

Funding

Wellcome Trust 220620
6 · The paper itself

Abstract

Enteroviruses can infect various human organs, causing diseases such as meningitis, the common cold, hand-foot-and-mouth disease, myocarditis, pancreatitis, hepatitis, poliomyelitis, sepsis, and type 1 diabetes. Currently, there are no approved treatments for enterovirus infections. In this study, we identified a synergistic combination of orally available, safe-in-man pleconaril, AG7404, and mindeudesivir, that at non-toxic concentrations effectively inhibited enterovirus replication in human cell and organoid cultures. Importantly, the cocktail did not alter glucose and insulin levels in the culture medium of pancreatic β-cells and preserved the contraction rhythm of infected heart organoids. These findings highlight a promising drug cocktail for further preclinical studies and clinical trials targeting a broad range of enterovirus-mediated diseases.

Indexed as

Antiviral AgentsEnterovirusEnterovirus InfectionsOrganoidsOxadiazolesAdministration, OralAnimalsDrug SynergismHumansInsulin-Secreting CellsOxazolesVirus ReplicationAntiviral AgentsOxadiazolesOxazolespleconarilAntiviral drug combinationBroad-spectrum antiviralsDrug synergyEnterovirus

Identifiers

PMID39843710
PMCPMC11754576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.