Evidence map›Paper›PMID 39843650›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Autoimmune Atypical Parkinsonism: A 10 year follow up of the original cohort.

Sreelakshmi Sunil Kumar, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Anandkumar Anandakuttan, Saraf Udit Umesh, Gopikrishnan Unnikrishnan, Meena Thevarkalam, Annamma Mathai, Uday Kumar Rangaswamy and 1 more

Abstract readObservational Study
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In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sreelakshmi Sunil KumarDepartment of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Sudheeran KannothDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India. sudheerank@aims.amrita.edu.ORCID http://orcid.org/0000-0001-7049-2774
Vivek NambiarDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Siby GopinathDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Anandkumar AnandakuttanDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Saraf Udit UmeshDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Gopikrishnan UnnikrishnanDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Meena ThevarkalamDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Annamma MathaiDepartment of Neurology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Uday Kumar RangaswamyDepartment of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.
Abish SudhakarDepartment of Paediatric Cardiology, Amrita Institute of Medical Sciences, Amrita Viswa Vidyapeetham University, Kochi, 682041, Kerala, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this research, we extend our initial study in 2016 of a distinct cohort diagnosed with autoimmune atypical parkinsonism, assessing the long-term effects of immunotherapy over a decade.

objectiveTo study the long-term effects of immunotherapy in patients with autoimmune atypical parkinsonism over 10 years.

designRetrospective Observational Study Design STUDY

settingThe study was carried out at the Department of Neurology at Amrita Institute of Medical Sciences, Kochi, Kerala. The cohort described in our previous study were followed up using data from EMR or by telecommunication. MEASUREMENTS: The authors utilized 9q-mRS scores to assess the disability scores and Kaplan-Meier life tables, using months as the time scale, to estimate the survival of patients with autoimmune atypical parkinsonism who underwent immunotherapy.

resultsSix out of 10 patients expired, but they experienced a good improvement in their 9q-mRS scores during their treatment. Out of the 4 surviving patients, 3 exhibited outstanding responses to immunotherapy while one maintained stable 9q-mRS over an extended period. Kaplan-Meier survival analysis revealed a mean survival time of 74.7 months and a median of 68 months, with 40% of cases censored.

conclusionsImmunotherapy significantly improved the disability scores in patients with autoimmune atypical parkinsonism.

Indexed as

Autoimmune DiseasesImmunotherapyParkinsonian DisordersAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesAutoimmune Atypical ParkinsonismImmunotherapyKaplan–Meier EstimateLong-term EffectsModified Rankin Scale (9q-mRS)Neuronal AntibodiesTherapeutic OutcomesTreatment Adherence and Discontinuation

Identifiers

PMID39843650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.