Evidence map›Paper›PMID 39843573›Full record

ArticleScientific reports2025

A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (N = 221,127).

Qi Pan, Yiwen Tao, Tengda Cai, Abi Veluchamy, Harry L Hebert, Peixi Zhu, Mainul Haque, Tania Dottorini, Lesley A Colvin, Blair H Smith and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The complexity of pain in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qi PanNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.
Yiwen TaoNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.
Tengda CaiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.
Abi VeluchamyDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF, UK.
Harry L HebertDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF, UK.
Peixi ZhuCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China.
Mainul HaqueSchool of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, 315100, China.
Tania DottoriniSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, LE12 5RD, UK.
Lesley A ColvinDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF, UK.
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF, UK.
Weihua MengNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. mengweihua888@hotmail.co.uk.

Funding

European Union's Horizon 2020 research and innovation programme 633491Ningbo International Collaboration Program 2023 2023H025Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 2023C04049
6 · The paper itself

Abstract

Hip pain is a common musculoskeletal complaint that leads many people to seek medical attention. We conducted a primary genome-wide association study (GWAS) on the hip pain phenotype within the UK Biobank cohort. Sex-stratified GWAS analysis approach was also performed to explore sex specific variants associated with hip pain. We found seven different loci associated with hip pain at GWAS significance level, with the most significant single nucleotide polymorphism (SNP) being rs77641763 within the EXD3 (p value = 2.20 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyOsteoarthritis, HipPolymorphism, Single NucleotideAgedBiological Specimen BanksCohort StudiesFemaleHipHumansMaleMiddle AgedUK BiobankUnited KingdomGenetic correlationsGenome-wide association studyHip painMendelian RandomizationPheWASSex-stratifiedUK Biobank

Identifiers

PMID39843573
PMCPMC11754597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.