Evidence map›Paper›PMID 39843551›Full record

ArticleScientific reports2025

The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients.

Napatsorn Kraivisitkul, Kajohnsak Noppakun, Chotiwit Sakuludomkan, Supavit Jirawattanapong, Siriaran Kwangsukstith, Nahathai Dukaew, Naruemon Suyayai, Mingkwan Na Takuathung, Nut Koonrungsesomboon

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Napatsorn KraivisitkulFaculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Kajohnsak NoppakunDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Chotiwit SakuludomkanDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Supavit JirawattanapongFaculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Siriaran KwangsukstithFaculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Nahathai DukaewDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Naruemon SuyayaiTransplant and Dialysis Unit, Medical Nursing Division, Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, 50200, Thailand.
Mingkwan Na TakuathungDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Nut KoonrungsesomboonDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. nkoonrung@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018-2021. Serum tacrolimus trough levels, urine BK viral load, and potential risk factors were collected. Statistical analysis was performed to identify the association between the serum tacrolimus trough levels and the detection of BK virus in urine (defined as positive BK viruria), as well as to determine the cumulative incidence and risk factors for BK viruria. Out of 243 recipients, 76 had positive BK viruria. The average serum tacrolimus trough level was significantly higher among the positive BK viruria group compared to the BK viruria-negative group. High HLA mismatch was identified as a risk factor for BK viruria. Approximately half of the recipients with average serum tacrolimus trough levels exceeding 10 ng/mL would develop BK viruria early. This study found an association between the average serum tacrolimus trough level and the detection of BK viruria. High HLA mismatch and an average serum tacrolimus trough level exceeding 10 ng/mL should be regarded as a risk for BK viruria.

Indexed as

BK VirusImmunosuppressive AgentsKidney TransplantationPolyomavirus InfectionsTacrolimusAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTransplant RecipientsViral LoadImmunosuppressive AgentsTacrolimusBK viruriaBK virus nephropathyRisk factorsTacrolimusTherapeutic drug monitoring

Identifiers

PMID39843551
PMCPMC11754913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.