Evidence map›Paper›PMID 39843534›Full record

Reviewnpj antimicrobials and resistance2024

Phage therapy could be key to conquering persistent bacterial lung infections in children.

Aye Mya Sithu Shein, Parichart Hongsing, Aisha Khatib, Phatthranit Phattharapornjaroen, Kazuhiko Miyanaga, Longzhu Cui, Kenji Shibuya, Mohan Amarasiri, Peter N Monk, Anthony Kicic and 4 more

Abstract readReview
In one paragraph

Review in npj antimicrobials and resistance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aye Mya Sithu SheinDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Parichart HongsingMae Fah Luang University Hospital, Chiang Rai, Thailand.
Aisha KhatibDepartment of Family & Community Medicine, University of Toronto, Toronto, ON, Canada.
Phatthranit PhattharapornjaroenFaculty of Health Science Technology, Chulabhorn Royal Academy, Bangkok, Thailand.
Kazuhiko MiyanagaDivision of Bacteriology, School of Medicine, Jichi Medical University, Tochigi, Japan.
Longzhu CuiDivision of Bacteriology, School of Medicine, Jichi Medical University, Tochigi, Japan.ORCID http://orcid.org/0000-0002-8909-3885
Kenji ShibuyaTokyo Foundation for Policy Research, Minato-ku, Tokyo, Japan.
Mohan AmarasiriDepartment of Civil and Environmental Engineering, Graduate School of Engineering, Tohoku University, Sendai, Miyagi, Japan.
Peter N MonkDepartment of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.ORCID http://orcid.org/0000-0003-4637-3059
Anthony KicicWal-yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Nedlands, 6009, WA, Australia. Anthony.Kicic@telethonkids.org.au.ORCID http://orcid.org/0000-0002-0008-9733
Tanittha ChatsuwanDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. Tanittha.C@chula.ac.th.
Paul G HigginsInstitute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Paul.Higgins@uni-koeln.de.ORCID http://orcid.org/0000-0001-8677-9454
Shuichi AbeDepartment of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Dhammika Leshan WannigamaDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. Dhammika.L@chula.ac.th.ORCID http://orcid.org/0000-0001-6316-1221

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demonstrating significant therapeutic benefits through various administration routes. Ongoing trials are evaluating its safety and effectiveness against different pathogens. Advancing phage therapy through systematic studies and international collaboration could provide a viable alternative to traditional antibiotics for persistent infections.

Identifiers

PMID39843534
PMCPMC11721074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.