Evidence map›Paper›PMID 39843509›Full record

ArticleScientific reports2025

Field switching of microfabricated metamagnetic FeRh MRI contrast agents.

Stephen Dodd, Natalia Gudino, Oleksii Zadorozhnii, Michal Staňo, Jan Hajduček, Jon Ander Arregi, H Douglas Morris, Vojtěch Uhlíř, Mladen Barbic, Alan P Koretsky

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephen DoddLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA. doddst@nih.gov.
Natalia GudinoLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
Oleksii ZadorozhniiCentral European Institute of Technology, Brno University of Technology (CEITEC BUT), Brno, 612 00, Czechia.
Michal StaňoCentral European Institute of Technology, Brno University of Technology (CEITEC BUT), Brno, 612 00, Czechia.
Jan HajdučekCentral European Institute of Technology, Brno University of Technology (CEITEC BUT), Brno, 612 00, Czechia.
Jon Ander ArregiCentral European Institute of Technology, Brno University of Technology (CEITEC BUT), Brno, 612 00, Czechia.
H Douglas MorrisDepartment of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Vojtěch UhlířCentral European Institute of Technology, Brno University of Technology (CEITEC BUT), Brno, 612 00, Czechia. vojtech.uhlir@ceitec.vutbr.cz.
Mladen BarbicTech4Health Institute, NYU School of Medicine, New York, NY, 10016, USA. Mladen.Barbic@nyulangone.org.
Alan P KoretskyLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a step towards generating switchable MRI cellular labels, we demonstrate in-situ field switching of micron scale metamagnetic Iron-Rhodium (FeRh) thin film particles. A thin-film (200 nm) FeRh sample was fabricated and patterned into an array of progressively smaller squares with sizes ranging from 500 μm down to 1 μm. The large first order phase change from antiferromagnetic to ferromagnetic state was characterized using vibrating sample magnetometry, magnetic force microscopy, and MRI. Room temperature MRI experiments sensitive to the local magnetic field surrounding the particles demonstrated the low moment state (OFF MRI contrast) at 4.7T and high moment state (ON MRI contrast) at 11.7T for the array where sizes down to 2-3 μm were observed in MRI at 50 μm resolution. The expected temperature dependent MRI contrast change was seen at 4.7T, where 10 μm particles could be observed at 150 μm resolution in the ON state. A shielded MRI insert, used to temporarily increase or decrease the magnetic field up to 0.77T amplitude, was used to reversibly switch the particle array at constant temperature and blink the particles ON and OFF at 4.7T. This work demonstrates the MRI contrast switching potential for FeRh particles with biological cell dimensions, and the use of magnetic field pulses for reversible MRI label contrast control.

Identifiers

PMID39843509
PMCPMC11754896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.