Evidence map›Paper›PMID 39843437›Full record

ArticleNature communications2025

RNA folding kinetics control riboswitch sensitivity in vivo.

David Z Bushhouse, Jiayu Fu, Julius B Lucks

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Design and discovery of 'tug-of-war' riboswitches.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David Z BushhouseInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-1987-0578
Jiayu FuInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL, USA.
Julius B LucksInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL, USA. jblucks@northwestern.edu.ORCID http://orcid.org/0000-0002-0619-6505

Funding

Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
Molecular Biophysics Training Program at Northwestern UniversityT32GM140995 · NIGMS · NORTHWESTERN UNIVERSITY · PI Heather Wendy Pinkett, Reza Vafabakhsh · 2021 to 2026
$2.5M
Functional Roles of Nascent RNA Structure in Regulating and Coordinating Gene Expression - supplementR01GM130901 · NIGMS · NORTHWESTERN UNIVERSITY · PI LUCKS, JULIUS BEAU · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM130901NIGMS NIH HHS T32 GM008382NIGMS NIH HHS T32 GM140995U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM130901U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008382
6 · The paper itself

Abstract

Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC

Indexed as

RiboswitchRNA, BacterialRNA FoldingAptamers, NucleotideGene Expression Regulation, BacterialKineticsLigandsNucleic Acid ConformationAptamers, NucleotideLigandsRiboswitchRNA, Bacterial

Identifiers

PMID39843437
PMCPMC11754884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.