ArticleCell death discovery2025
Thy1-YFP: an effective tool for single cell tracing from neuronal progenitors to mature functionally active neurons.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.Cell death & disease · 2026Article
- Context-tuned strategies for marker selection precision in neuronal studies.Frontiers in neuroscience · 2026Review
- Extremely low-frequency electromagnetic fields facilitate proliferation and functional differentiation in spinal neural stem cells.Scientific reports · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The differentiation of mouse neurons is a complex process involving cell maturation and branching, occurring during both, embryonic development and differentiation in vitro. To study mouse neuronal morphology, we used the Thy1 YFP-16 mouse strain. Although this mouse strain was described over twenty years ago, detailed studies on projections outgrowth and morphology of neurons are still lacking. The main goal of our study was to analyse the differentiation patterns of neural stem cells, including markers of differentiation, colocalization patterns, synaptic markers and the tracing of cell projections during differentiation in vitro. The neural stem cells were isolated from embryos at embryonic day 14.5 as well as newborn pups and differentiated into neurons and astrocytes. Our data showed a significant decrease of neural stem cells markers and a substantial increase in neuronal markers during differentiation, analysed by immunocytochemistry, quantitative PCR and western blot. To assess synaptic maturation, neurons were further analysed by quantitative PCR and immunocytochemistry. Expression of synaptic markers were increased during differentiation in vitro. At the 7
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