Evidence map›Paper›PMID 39843249›Full record

Trial reportObesity (Silver Spring, Md.)2025

Grocery intervention and DNA-based assessment to improve diet quality in pediatric obesity: a pilot randomized controlled study.

Ammara Aqeel, Melissa C Kay, Jun Zeng, Brianna L Petrone, Chengxin Yang, Tracy Truong, Covington B Brown, Sharon Jiang, Veronica M Carrion, Stephanie Bryant and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Management of Childhood Obesity.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ammara AqeelDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-0205-9412
Melissa C KayDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jun ZengDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Brianna L PetroneDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Chengxin YangDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Tracy TruongDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Covington B BrownDepartment of Nutrition, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sharon JiangDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Veronica M CarrionDuke Office of Clinical Research, Duke University School of Medicine, Durham, North Carolina, USA.
Stephanie BryantDepartment of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Michelle C KirtleyDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Cody D NeshterukDuke Center for Childhood Obesity Research, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-0516-6873
Sarah C ArmstrongDuke Center for Childhood Obesity Research, Duke University School of Medicine, Durham, North Carolina, USA.
Lawrence A DavidDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
Institutional Career Development CoreKL2TR002554 · NCATS · DUKE UNIVERSITY · PI SVETKEY, LAURA P · 2018 to 2022
$8.2M
Personalizing prebiotic therapies that target human gut microbiotaR01DK116187 · NIDDK · DUKE UNIVERSITY · PI Lawrence Anthony David · 2018 to 2026
$3.7M
Using DNA sequencing to assess dietary species richnessR01DK128611 · NIDDK · DUKE UNIVERSITY · PI Lawrence Anthony David · 2022 to 2026
$2.9M
Burroughs Wellcome Fund Pathogenesis of Infectious Disease AwardChan Zuckerberg InitiativeDuke Clinical and Translational Science AwardDuke Microbiome CenterNCATS NIH HHS 1KL2TR002554NCATS NIH HHS KL2 TR002554NCATS NIH HHS UL1 TR002553NCATS NIH HHS UL1TR002553NIDDK NIH HHS R01 DK116187NIDDK NIH HHS R01-DK116187-06A1NIDDK NIH HHS R01 DK128611NIDDK NIH HHS R01-DK128611-01A1
6 · The paper itself

Abstract

objectiveWe assessed the impact of a food-provisioning intervention on diet quality in children with obesity.

methodsParticipants (n = 33, aged 6-11 years) were randomly assigned to either usual care (intensive health behavior and lifestyle treatment) or intervention (usual care + food provisioning; high-fiber, low-dairy diet) for 4 weeks. The primary outcome was a change in child diet quality at Week 4. Secondary outcomes were changes in weight, food insecurity, gut microbiome composition (16S ribosomal RNA), and dietary intake, measured via an objective DNA-based biomarker (i.e., FoodSeq). Genomic dietary data were analyzed against a larger pediatric adolescent obesity cohort (n = 195, aged 10-18 years) from similar households.

resultsIntervention demonstrated changes across all assessed diet components and was more effective than usual care in increasing whole grain (β = 0.20, 95% CI: 0.05 to 0.34; p = 0.013) and fiber (β = 2.52, 95% CI: 1.28 to 3.76; p < 0.001) and decreasing dairy (β = -1.31, 95% CI: -2.02 to -0.60; p = 0.001). FoodSeq results, highly concordant with grocery orders (adjusted R

conclusionsOur study supports the potential of dietitian-guided food provisioning for improving diet quality in children with obesity and demonstrates an objective genomic approach for evaluating dietary shifts.

Indexed as

DietPediatric ObesityAdolescentChildDietary FiberFemaleFood InsecurityGastrointestinal MicrobiomeHealth BehaviorHumansLife StyleMalePilot ProjectsDietary Fiber

Identifiers

PMID39843249
PMCPMC11977789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.