Evidence map›Paper›PMID 39842938›Full record

ArticleOpen heart2025

Temporal order of atrial fibrillation and acute myocardial infarction and associated prognosis in the Danish Diet, Cancer and Health cohort.

Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J Benjamin, Anja Olsen, Henrik Kjærulf Jensen, Christina C Dahm

Abstract readMulticenter Study
In one paragraph

Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Age-Stratified Mortality Impact of Atrial Fibrillation in Elderly NSTEMI Patients.Journal of cardiovascular development and disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tanja Charlotte FrederiksenDepartment of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark tanja_charlotte@clin.au.dk.ORCID http://orcid.org/0000-0003-3338-9297
Morten Krogh ChristiansenDepartment of Cardiology, Viborg Regional Hospital, Viborg, Denmark.
Emelia J BenjaminSection of Cardiovascular Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Anja OlsenDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Henrik Kjærulf JensenDepartment of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.
Christina C DahmDepartment of Public Health, Aarhus University, Aarhus, Denmark.

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
NHLBI NIH HHS R01 HL092577
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) and acute myocardial infarction (AMI) share risk factors and are bidirectionally associated. Several studies found higher risks of outcomes in individuals with both conditions. Whether the risks of outcomes differ according to temporal order of AF and AMI is unclear.

methodsThe study was based on the Danish Diet, Cancer and Health cohort. We assessed the risk of heart failure (HF), ischaemic stroke (IS) and all-cause mortality during 10 years of follow-up in participants with both AF and AMI compared with only one and according to the temporal order of AF and AMI in participants with both conditions.

resultsWe identified 5816 participants with newly diagnosed AF only, 3448 with first AMI only, 348 with AF before AMI and 721 participants with AMI before AF. The multivariable-adjusted risks of HF, IS and all-cause mortality were higher among participants with both AF and AMI compared with participants with only AF or AMI. In participants with both, there was no difference in risk of HF (HR 0.92, 95% CI 0.72 to 1.17) or IS (HR 1.12, 95% CI 0.76 to 1.66) between participants with AF before AMI compared with AMI before AF. AMI before AF was associated with lower all-cause mortality compared with AF before AMI (HR 0.70, 95% CI 0.54 to 0.90).

conclusionsRisks of adverse outcomes were higher among participants with both AF and AMI compared with only AF or AMI. All-cause mortality, but not risk of HF or IS, differed according to temporal order with a lower mortality among participants with AMI before AF.

Indexed as

Atrial FibrillationMyocardial InfarctionAgedCause of DeathDenmarkFemaleFollow-Up StudiesHeart FailureHumansIncidenceMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsTime FactorsAcute Coronary SyndromeAtrial FibrillationEpidemiologyRisk Factors

Identifiers

PMID39842938
PMCPMC11759883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.