Behavioral adaptations after unilateral whisker denervation.

Patrick Wright, Eleanor McCall, Sean Collier, Fred Johnson, Laxmi Iyer, Alan P Koretsky, Emily Petrus

Abstract read

In one paragraph

Article in Behavioural brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patrick WrightNational Institute of Neurological Disorders and Stroke (NINDS) Intramural Program, Bethesda, MD, USA.

Eleanor McCallNeuroscience Program, Emory University, Atlanta, GA, USA.

Sean CollierNeuroscience Program, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Fred JohnsonHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Laxmi IyerHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Alan P KoretskyNational Institute of Neurological Disorders and Stroke (NINDS) Intramural Program, Bethesda, MD, USA.

Emily PetrusNeuroscience Program, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: emily.petrus@usuhs.edu.

Funding

The Mechanisms and Functional Consequences of Interhemispheric PlasticityR00NS112612 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PETRUS, EMILY ROSE · 2022 to 2024

$740k

NINDS NIH HHS R00 NS112612

6 · The paper itself

Abstract

The rodent whisker system provides an excellent model to study experience dependent plasticity in neural morphology, circuitry, and behavior. Rodents use bilateral whisker sensation to gather information about their environment. Unilateral whisker denervation disrupts whisker circuitry but its impact on task specific behavior is largely unknown. Adult mice with unilateral whisker denervation display a preference to using the intact whisker set to inspect objects, but do not have altered open field navigation. An object localization task requiring only the intact whisker set did not detect any change in performance, but gap crossing was impaired after unilateral whisker denervation. Finally, chronic whisker denervation led to increased anxiety-like behavior which was rescued by training on the gap cross task. These findings indicate that mice use behavioral strategies to adapt to life with only one set of intact whiskers.

Indexed as

Adaptation, PhysiologicalBehavior, AnimalVibrissaeAnimalsAnxietyDenervationMaleMiceMice, Inbred C57BLAnxiety after injuryMouse behaviorWhisker denervation/deprivationWhisker task

Identifiers

PMID39842643

DOI10.1016/j.bbr.2025.115435

PMCPMC13501243

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.