Evidence map›Paper›PMID 39842634›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2025

Intergenerational Impacts of Historical Trauma on Contemporary Depression Symptoms Among Indigenous Communities.

Ashley B Cole, Kelley J Sittner, Trisha Bruyere, Melissa L Walls

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Understanding one First Nations community's ways of healing from historical trauma.Psychological trauma : theory, research, practice and policy · 2026
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashley B ColeOklahoma State University, Stillwater, Oklahoma. Electronic address: abcole@okstate.edu.
Kelley J SittnerOklahoma State University, Stillwater, Oklahoma.
Trisha BruyereJohns Hopkins University, Duluth, Minnesota.
Melissa L WallsJohns Hopkins University, Duluth, Minnesota.

Funding

Research Project 3P50DA058619 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Melissa L. Walls · 2023 to 2026
$12.9M
Towards understanding the influence of greenspace and blue-space exposure mediated by culture-based human-nature interaction on onset of substance use among Indigenous youth.R01DA039912 · NIDA · UNIVERSITY OF MINNESOTA · PI SITTNER, KELLEY, WALLS, MELISSA L. · 2016 to 2025
$6.4M
Stress and Type 2 Diabetes among Indigenous AdultsR01DK091250 · NIDDK · UNIVERSITY OF MINNESOTA · PI WALLS, MELISSA L. · 2012 to 2024
$5.7M
Mobile Health to Monitor Risk for COVID-19 and Improve Mental Health during the PandemicR01MH126586 · NIMH · UNIVERSITY OF HOUSTON · PI BUSINELLE, MICHAEL S., ZVOLENSKY, MICHAEL J. · 2021 to 2023
$2.8M
Tobacco Cessation among American Indian Cancer Survivors in Cherokee NationP20CA253255 · NCI · CHEROKEE NATION · PI KHAN, SOHAIL IMRAN · 2020 to 2023
$697k
NCI NIH HHS P20 CA253255NIDA NIH HHS P50 DA058619NIDA NIH HHS R01 DA039912NIDDK NIH HHS R01 DK091250NIMH NIH HHS R01 MH126586
6 · The paper itself

Abstract

objectiveIndigenous communities in the United States and Canada have endured generations of historical trauma. In the face of ongoing marginalization, Indigenous Peoples persist, resist, and thrive. Simultaneously, the consequences of historical trauma are vast and enduring. For instance, there is significant variation in how depression symptoms unfold over the life course. The aim of this study is to examine longitudinal, intergenerational associations between historical trauma and depression symptoms among Indigenous young adults.

methodAnalyses include data from target participants (ie, children at baseline) and their primary female caregivers (eg, parents) from Healing Pathways (HP), a community-based participatory study that began in 2001/2002 with families from 8 First Nations in the United States and Canada. All eligible children (10-12-years of age at baseline, enrolled tribal members, living on/near reserve land) and at least one of their caregivers were invited to participate, and were interviewed annually for 8 years. Three additional years of interviews were conducted starting in 2017 with baseline-enrolled children, now young adults. Caregivers and their now young adult children completed measures of depression symptoms, family boarding/residential school (BRS) history, and other family sociodemographic variables.

resultsGroup-based trajectory modeling identified 4 depression symptom trajectory groups: low (28.7%), decreasing (26.6%), increasing (22.4%), and high (22.3%). Multinomial logistic regression analyses, with the low symptom group as the referent group, revealed that familial BRS history doubled the odds of being in the high symptom group (odds ratio = 2.05, p < .05) compared to the low symptom group. Being female, experiencing discrimination, and caregiver (eg, parental) history of depression increased the odds of being in the high symptom group, whereas experiencing warm and supportive parenting decreased the odds of being in the high symptom group.

conclusionThe intergenerational effects of historical trauma remain ongoing and harmful to Indigenous populations. Current findings illuminate several factors that may be particularly salient among subsequent Indigenous generations, and provide implications for prevention efforts. PLAIN LANGUAGE SUMMARY: This study examined longitudinal data of children and their primary female caregivers from Healing Pathways, a community-based participatory study with 525 Indigenous families from 8 First Nations in the US and Canada that began in 2001 and 2002 when the child participants were 10 to 12 years old and followed them until they were 24 to 29. Multinomial logistic regression analyses revealed that having a familial boarding residential school history, being female, experiencing discrimination, and caregiver history of depression increased the odds of having depression, while experiencing warm and supportive parenting decreased the odds of depression into adulthood for Indigenous now-young adults. That both discrimination and familial experiences of historical trauma were associated with depression symptoms underscores the need for the development of population-based mental health interventions. DIVERSITY & INCLUSION STATEMENT: We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. Diverse cell lines and/or genomic datasets were not available. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. One or more of the authors of this paper received support from a program designed to increase minority representation in science. While citing references scientifically relevant for this work, we also actively worked to promote sex and gender balance in our reference list.

Indexed as

DepressionHistorical TraumaIndians, North AmericanIndigenous CanadiansIntergenerational RelationsAdolescentAdultCanadaCaregiversChildCommunity-Based Participatory ResearchFemaleHumansLongitudinal StudiesMaleUnited Statesdepression symptomshistorical traumaIndigenousintergenerational trauma

Identifiers

PMID39842634
PMCPMC12980653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.