Evidence map›Paper›PMID 39842480›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025

Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences.

Christine T Major-Styles, Jack Munns, Aiwei Zeng, Michael Vanden Oever, John S O'Neill, Rachel S Edgar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  2. Development of compounds for targeted degradation of mammalian cryptochrome proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  3. Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christine T Major-StylesDepartment of Infectious Disease, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-7337-2540
Jack MunnsMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0009-0001-6603-0988
Aiwei ZengDepartment of Infectious Disease, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-0354-2529
Michael Vanden OeverDepartment of Infectious Disease, Imperial College London, London SW7 2AZ, UK.
John S O'NeillMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-2204-6096
Rachel S EdgarDepartment of Infectious Disease, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-3348-0851

Funding

Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

The within-host environment changes over circadian time and influences the replication and severity of viruses. Genetic knockout of the circadian transcription factors CRYPTOCHROME 1 and CRYPTOCHROME 2 (

Indexed as

CryptochromesInfluenza A virusOrthomyxoviridae InfectionsAnimalsFibroblastsMiceMice, KnockoutSignal TransductionCry1 protein, mouseCry2 protein, mouseCryptochromescircadian rhythmsCRYPTOCHROMEintegrated stress responseinterferonprotein homeostasisvirus

Identifiers

PMID39842480
PMCPMC11753882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.