Evidence map›Paper›PMID 39842429›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Promotion or inhibition? This is a question in gene editing.

Li-Kuang Tsai, Renzhi Han, Dongshan Yang, Y Eugene Chen, Jifeng Zhang, Jie Xu

Abstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li-Kuang TsaiCenter for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Renzhi HanDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Dongshan YangCenter for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Y Eugene ChenCenter for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Jifeng ZhangCenter for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address: jifengz@med.umich.edu.
Jie XuCenter for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address: jiex@med.umich.edu.

Funding

Controllable base editing therapy for DMDR01HL170260 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Renzhi Han · 2023 to 2026
$2.4M
Targeted editing of ASGR1 for cardiovascular diseasesR01HL169976 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI YUQING Eugene CHEN, Renzhi Han · 2024 to 2026
$2.1M
Novel methods to improve nuclease mediated homologous recombination, Administrative supplR42GM122181 · NIGMS · ATGC, INC. · PI ZHANG, JIFENG · 2022 to 2023
$2.1M
NHLBI NIH HHS R01 HL169976NHLBI NIH HHS R01 HL170260NIGMS NIH HHS R42 GM122181
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39842429
PMCPMC11852673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.