ArticleEnvironmental science & technology2025
Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- MALDI mass spectrometry imaging across spatial scales in toxicology: tissue evidence, cellular heterogeneity, and emerging single-cell opportunities.Analytical and bioanalytical chemistry · 2026Review
- Multi-Omics-Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation.Chemical biology & drug design · 2026Review
- Towards spatial lipid profiling by using mass spectrometry: analytical challenges and applications.Analytical and bioanalytical chemistry · 2026Review
- Novel Insights into the Distribution and Effects of Perfluorooctanesulfonic acid (PFOS) in the Nervous System of a Frog Tadpole Model by Mass Spectrometry Imaging.Environmental science & technology · 2026Article
- Engineered Reactive Interfaces Enable Mass Spectrometry Imaging of Multiple Thiols for Decoding PFOS-Induced Redox Dysregulation.Analytical chemistry · 2026Article
- A Comprehensive, Simple, Robust, and Solvent-Free Method Covering Ultrashort- to Long-Chain PFAS in Atmospheric Samples.Analytical chemistry · 2025Article
- Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression.Theranostics · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution and bioaccumulation of environmental pollutants are essential to understanding their toxicological mechanism. However, achieving spatial resolution at the subtissue level is still challenging. Perfluorooctanesulfonate (PFOS) is a persistent environmental pollutant with widespread occurrence. The bioaccumulation behavior of PFOS is complicated by its dual affinity for phospholipids and protein albumin. It is intriguing to visualize the distribution preference of PFOS and investigate the differential microenvironment responses at a subtissue level. Herein, we developed a mass-spectrometry (MS)-based spatial multiomics workflow, integrating matrix-assisted laser desorption/ionization MS imaging, laser microdissection, and liquid chromatography MS analysis. This integrated workflow elucidates the spatial distribution of PFOS in mouse cardiac tissue, highlighting its preferential accumulation in the pericardium over the myocardium. This distribution pattern results in greater toxicity to the pericardium, significantly altering cardiolipin levels and disrupting energy metabolism and lipid transport pathways. Our integrated approach provides novel insights into the bioaccumulation behavior of PFOS and demonstrates significant potential for revealing complex molecular mechanisms underlying the health impacts of environmental pollutants.
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Registered trials
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