Evidence map›Paper›PMID 39841849›Full record

ArticleScience advances2025

Dynamic molecular architecture of the synaptonemal complex.

Simone Köhler, Michal Wojcik, Ke Xu, Abby F Dernburg

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  5. High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Multi-step implementation of meiotic crossover patterning.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A suppressor screenProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. A suppressor screenbioRxiv : the preprint server for biology · 2023
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simone KöhlerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.ORCID 0000-0002-1119-8855
Michal WojcikDepartment of Chemistry, University of California, Berkeley, Berkeley CA 94720-3220, USA.ORCID 0000-0002-0053-1018
Ke XuDepartment of Chemistry, University of California, Berkeley, Berkeley CA 94720-3220, USA.ORCID 0000-0002-2788-194X
Abby F DernburgDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.ORCID 0000-0001-8037-1079

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Crossover control during meiosisR01GM065591 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DERNBURG, ABBY F · 2002 to 2021
$4.5M
Intracellular transport and organelle biology at the nanoscale: A multidimensional super-resolution approachR35GM149349 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ke Xu · 2023 to 2026
$1.8M
NIGMS NIH HHS R01 GM065591NIGMS NIH HHS R35 GM149349NIH HHS P40 OD010440
6 · The paper itself

Abstract

During meiosis, pairing between homologous chromosomes is stabilized by the assembly of the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and regulates their distribution. However, how the SC regulates crossover formation remains elusive. We isolated an unusual mutation in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsSynaptonemal ComplexAnimalsCrossing Over, GeneticMeiosisMutationCaenorhabditis elegans Proteins

Identifiers

PMID39841849
PMCPMC11753403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.