ArticleScience advances2025
Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Spatiotemporal distribution trends and driving factors of avian influenza in poultry in China.One health (Amsterdam, Netherlands) · 2026Article
- Rapid Expansion of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Genotype D1.1 Virus across Flyway Regions, North America, Fall 2024.Emerging infectious diseases · 2026Article
- Evolving dynamics of H5Nx avian influenza in China revealed by long-term wild bird surveillance.Nature communications · 2026Article
- Environmental samples, a sensitive and practical alternative to individual bird sampling in the surveillance of H9N2 vaccinated turkey flocks.The Journal of general virology · 2026Article
- Comparing frequentist and Bayesian methods to identify drivers of pathogen strain invasion: A temporal case study of pertussis in the United States.Infectious Disease Modelling · 2026Article
- Algorithm-Optimized H5 Influenza mRNA Vaccine Induces Broad Immune Responses.International journal of molecular sciences · 2026Article
- Human infections with avian influenza A(H5) viruses with potential pandemic risk: 1997-2025.National science review · 2026Article
- The emergence and molecular evolution of H5N1 influenza viruses in United States dairy cattle.bioRxiv : the preprint server for biology · 2026Article
- Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses.Nature reviews. Microbiology · 2026Review
- Genetic strategies for avian influenza resilience in poultry: from host-pathogen interaction studies to precision breeding.Functional & integrative genomics · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
The effectiveness of poultry vaccination in preventing the transmission of highly pathogenic avian influenza viruses (AIVs) has been debated, and its impact on wild birds remains uncertain. Here, we reconstruct the movements of H5 subtype AIV lineages among vaccinated poultry, unvaccinated poultry, and wild birds, worldwide, from 1996 to 2023. We find that there is a time lag in viral transmission among different host populations and that movements from wild birds to unvaccinated poultry were more frequent than those from wild birds to vaccinated poultry. Furthermore, our findings suggest that the HA (hemagglutinin) gene of the AIV lineage that circulated predominately in Chinese poultry experienced greater nonsynonymous divergence and adaptive fixation than other lineages. Our results indicate that the epidemiological, ecological, and evolutionary consequences of widespread AIV vaccination in poultry may be linked in complex ways and that much work is needed to better understand how such interventions may affect AIV transmission to, within, and from wild birds.
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