Evidence map›Paper›PMID 39841840›Full record

ArticleScience advances2025

Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.

Peng Cao, Ying Liu, Ziyun Ni, Mingjun Zhang, Hong-Rui Wei, An Liu, Jin-Rong Guo, Yumeng Yang, Zheng Xu, Yuyu Guo and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Article
  4. Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peng CaoDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0009-0001-6712-429X
Ying LiuDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0009-0004-0084-9087
Ziyun NiDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-1314-7963
Mingjun ZhangDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-8483-8171
Hong-Rui WeiDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-7511-1747
An LiuDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China.
Jin-Rong GuoDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China.
Yumeng YangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China.ORCID 0009-0001-8801-185X
Zheng XuNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China.
Yuyu GuoDepartment of Pain Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Zhi ZhangDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-4205-3181
Wenjuan TaoDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China.ORCID 0000-0002-0525-0514
Likui WangDepartment of Pain Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.ORCID 0000-0001-5376-351X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prosocial behaviors are advantageous to social species, but the neural mechanism(s) through which others receive benefit remain unknown. Here, we found that bystander mice display rescue-like behavior (tongue dragging) toward anesthetized cagemates and found that this tongue dragging promotes arousal from anesthesia through a direct tongue-brain circuit. We found that a direct circuit from the tongue → glutamatergic neurons in the mesencephalic trigeminal nucleus (MTN

Indexed as

ArousalBehavior, AnimalBrainSocial BehaviorTongueAnesthesiaAnimalsLocus CoeruleusMaleMiceMice, Inbred C57BLNeurons

Identifiers

PMID39841840
PMCPMC11753405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.