Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Makoto TonshoCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0009-0008-5706-6795
Jane M OCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-6260-238X
Kaitlan AhrensCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-3205-3866
Kortney RobinsonCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4731-5558
Wiebke SommerCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0009-0003-1452-1157
Svjetlan BoskovicCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Parth M PatelCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-3198-1916
David C BecerraCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Kyu Ha HuhCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1364-6989
Cynthia L MillerCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1720-8222
Abbas DehnadiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1226-9413
Isabel HanekampCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-6218-3979
Ivy A RosalesDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0621-3202
Robert B ColvinDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4493-4150
David H SachsCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Alessandro AlessandriniCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0347-1927
A CosimiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Robert L FairchildDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-7107-5259
Paolo CravediTranslational Transplant Research Center and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sofia BinTranslational Transplant Research Center and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peter S HeegerComprehensive Transplant Center, Cedars-Sinai Medical Center, West Hollywood, CA 90048, USA.ORCID 0000-0003-4673-6913
James S AllanCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-6499-1443
Tatsuo KawaiCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-6900-4603
Gilles BenichouCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1356-3171
Joren C MadsenCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-2724-1333
Funding
XENOGRAFT TOLERANCE THROUGH MIXED CHIMERISMP01AI045897 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Megan Sykes · 2000 to 2026
$71.9M
XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
Project 2: The New Era of Cellular Therapies For Lung Transplant ToleranceU19AI174967 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Joren C Madsen · 2023 to 2026
$18.8M
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft ToleranceP01HL158504 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2021 to 2025
$12.1M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
TRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1998 to 2024
$6.4M
Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantationU01AI131470 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2017 to 2022
$5.6M
Pathways to Mentorship and Research: Training the Next Generation Physician-ScientistsR25AI147393 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2019 to 2024
$1.8M
Effects of Lymphangiogenesis Blockade on Skin Allograft RejectionR21AI100278 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BENICHOU, GILLES A · 2012 to 2013
$370k
Versatile high-throughput Alinity ci assay platform to support multiple laboratory animal usersS10OD034375 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI PIERSON, RICHARD N · 2024 to 2024
Long-term, immunosuppression-free allograft survival has been induced in human and nonhuman primate (NHP) kidney recipients after nonmyeloablative conditioning and donor bone marrow transplantation (DBMT), resulting in transient mixed hematopoietic chimerism. However, the same strategy has consistently failed in NHP heart transplant recipients. Here, we investigated whether long-term heart allograft survival could be achieved by cotransplanting kidneys from the same donor. Cynomolgus monkeys were transplanted with heart allografts alone or heart and kidney allografts from the same major histocompatibility complex (MHC)-mismatched donors. All animals except one received DBMT, either at the same time or after a 2- to 4-month delay, plus short-term costimulation blockade and calcineurin inhibitor treatment. Long-term, immunosuppression-free heart allograft survival was consistently achieved in heart/kidney, but not heart-alone, recipients. This was not associated with greater donor/recipient histocompatibility or altered lymphoid cell reconstitution after conditioning. The maintenance of tolerance after heart/kidney transplantation was associated with the presence of forkhead box P3 (Foxp3
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation. · full record | OpenQuestion