Evidence map›Paper›PMID 39841789›Full record

ArticleBiomacromolecules2025

Fast-Relaxing Hydrogels Promote Pancreatic Adenocarcinoma Cell Aggressiveness through Integrin β1 Signaling.

Han Nguyen, Ngoc Ha Luong, Jacqueline K Peil, Yan Tong, Dana K Mitchell, Melissa L Fishel, Chien-Chi Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han NguyenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Ngoc Ha LuongWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Jacqueline K PeilDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Yan TongDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Dana K MitchellDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Melissa L FishelDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-9436-6382
Chien-Chi LinWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-4175-8796

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Novel Role of Ref-1 in Pancreatic Cancer Etiology and ProgressionR01CA167291 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI FISHEL, MELISSA L., KELLEY, MARK R. · 2013 to 2022
$5.2M
Reprogramming PDAC Stroma by Targeting Coagulation in the Tumor MicroenvironmentU01CA274304 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Melissa L. Fishel, Matthew J. Flick · 2022 to 2026
$4.6M
Targeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2M
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitorsR01CA254110 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI FISHEL, MELISSA L., HAN, BUMSOO · 2021 to 2025
$2.1M
Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancerR01CA282478 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Melissa L. Fishel, Mark R. Kelley · 2023 to 2026
$2.1M
A Fragment-Based Strategy for K-RAS Covalent InhibitorsR01CA264471 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MEROUEH, SAMY · 2021 to 2024
$1.9M
BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia: Admin SuppR01CA227737 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, CHIEN-CHI · 2019 to 2022
$1.5M
NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA167291NCI NIH HHS R01 CA227737NCI NIH HHS R01 CA254110NCI NIH HHS R01 CA264471NCI NIH HHS R01 CA282478NCI NIH HHS U01 CA274304NHLBI NIH HHS U01 HL143403
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense extracellular matrix (ECM) exhibiting high stiffness and fast stress relaxation. In this work, gelatin-based viscoelastic hydrogels were developed to mimic the compositions, stiffness, and fast stress relaxation of PDAC tissues. The hydrogels were cross-linked by gelatin-norbornene-boronic acid (GelNB-BA), thiolated macromers, and a 1,2-diol-containing linear synthetic polymer PHD. Controlling the thiol-norbornene cross-linking afforded tunable stiffness, whereas increasing PHD content led to hydrogels with PDAC-mimicking fast stress relaxation.

Indexed as

Carcinoma, Pancreatic DuctalHydrogelsIntegrin beta1Pancreatic NeoplasmsAnimalsCell Line, TumorCell ProliferationEpithelial-Mesenchymal TransitionGelatinHumansMiceMice, NudeSignal TransductionGelatinHydrogelsIntegrin beta1Itgb1 protein, human

Identifiers

PMID39841789
PMCPMC11817685

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.