Evidence map›Paper›PMID 39841785›Full record

ArticleACS nano2025

Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury.

Shijie Yang, Borui Xue, Yongfeng Zhang, Haining Wu, Beibei Yu, Shengyou Li, Teng Ma, Xue Gao, Yiming Hao, Lingli Guo and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Extracellular vesicle-based therapeutic strategies for spinal cord injury.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shijie YangDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Borui XueDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Yongfeng ZhangDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Haining WuDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Beibei YuDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Shengyou LiDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Teng MaDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Xue GaoDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Yiming HaoDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Lingli GuoDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Qi LiuDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Xueli GaoSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710072, P.R. China.
Yujie YangDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Zhenguo WangDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Mingze QinDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Yunze TianDepartment of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Longhui FuDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Bisheng ZhouDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Luyao LiDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Jianzhong LiDepartment of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Shouping GongDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710004, P.R. China.
Bing XiaDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Jinghui HuangDepartment of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.ORCID 0000-0002-0991-0591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deer antler blastema progenitor cells (ABPCs) are promising for regenerative medicine due to their role in annual antler regeneration, the only case of complete organ regeneration in mammals. ABPC-derived signals show great potential for promoting regeneration in tissues with limited natural regenerative ability. Our findings demonstrate the capability of extracellular vesicles from ABPCs (EVs

Indexed as

AntlersExtracellular VesiclesMesenchymal Stem CellsNeural Stem CellsNeurogenesisRegenerationSpinal Cord InjuriesAnimalsBone Marrow CellsCell EngineeringCell-Penetrating PeptidesCell ProliferationFemaleMaleNeuronal OutgrowthRatsCell-Penetrating Peptidesantler blastema progenitor cellsaxonal growthextracellular vesiclesneural stem cellsspinal cord injury

Identifiers

PMID39841785
PMCPMC11841045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.