Evidence map›Paper›PMID 39841635›Full record

ArticleEuropean thyroid journal2025

Differences and analogies in thyroid cancer discovered incidentally or by thyroid related screening: A multicenter study.

Laura Croce, Rosaria Maddalena Ruggeri, Camilla Virili, Carlo Cappelli, Marsida Teliti, Pietro Costa, Spyridon Chytiris, Antonio Nicocia, Francesca Coperchini, Maria Flavia Bagaglini and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European thyroid journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura CroceL Croce, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Rosaria Maddalena RuggeriR Ruggeri, Department of Human Pathology and Childhood "G. Barresi", University of Messina, Messina, Italy.
Camilla ViriliC Virili, Department of Medico-Surgical Sciences and Biotechnologies, University of Rome La Sapienza, Rome, Italy.
Carlo CappelliC Cappelli, SSVD Endocrinologia, Università degli Studi di Brescia, Brescia, Italy.
Marsida TelitiM Teliti, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Pietro CostaP Costa, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Spyridon ChytirisS Chytiris, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Maugeri Clinical Research Institutes IRCCS, Pavia, Italy.
Antonio NicociaA Nicocia, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.
Francesca CoperchiniF Coperchini, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Maria Flavia BagagliniM Bagaglini, Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.
Flavia MagriF Magri, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Alfredo CampenniA Campenni, BIOMORF, University of Messina, Messina, Italy.
Mario RotondiM Rotondi, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prevalence of Thyroid-Cancer (TC) has increased worldwide and an association with metabolic and cardio-vascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid related imaging for other clinical conditions. Our aim was to assess the prevalence of Thyroid-Related (TD) versus Incidental (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities.

designwe performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. PATIENTS: Consecutive patients with TC Measurements: data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardio-metabolic comorbidities and non-thyroid cancer.

resultsamong the 327 enrolled subjects the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones, they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extra-thyroidal extension, lymph-node metastases, AJCC Staging or ATA Risk stratification.

conclusionsbiological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features.

Indexed as

Incidental FindingsThyroid NeoplasmsAdultAgedCardiovascular DiseasesComorbidityFemaleHumansItalyMaleMiddle AgedPrevalenceRetrospective Studies

Identifiers

PMID39841635
PMCPMC11825167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.